The Pancyprian Gymnasium (Greek: Παγκύπριον Γυμνάσιον, romanized: Pankýprion Gymnásion) is the oldest still operational high school in Cyprus, founded in 1812.

In the location of the current school, an older school existed, established in 1753 known as Ellinomouseion (Greek: Ελληνιμουσείον).

The Pancyprian Gymnasium was founded in 1812, by Archbishop Kyprianos, at a time when Cyprus was still under Ottoman rule. It was originally called the Hellenic School of Nicosia (Greek: Ελληνική Σχολή Λευκωσίας) and is the oldest high school in operation on the island. The first principal of the Gymnasium in 1893 was Delios Ioannis. The school was expanded in 1893, by the initiative of Archbishop Sophronius III, to incorporate a lyceum when Cyprus was under British rule, therefore making it equal to Greek high schools, deeming its students eligible to study at the University of Athens.

In 1894 aside from the secondary school, a school for primary school teachers was founded, the Didaskaleio (Greek: Διδασκάλειο). In 1896 it changed its name to its current one.

Students of the school have fought in the Greek War of Independence, Greco-Turkish War of 1897, the Balkan Wars and participated in the EOKA struggle.

In tribute to the school's contribution to education the Cyprus Post office issued a commemorative stamp in 1993.

It is located opposite the archbishopric within the walls of the old city of Nicosia. The original building was destroyed in a fire in 1920 and parts of the school were completely rebuilt in neoclassical style. The gymnastics facilities are being renovated as of the 2025-2026 academic year.

Of particular historical interest is the crypt of the school located beneath the main entrance. This is where Archbishop Kyprianos was said to have held secret meetings with representatives of the Philiki Etairia in the early 19th century.