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Primitive streak
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Primitive streak
The primitive streak is a structure that forms in the early embryo in amniotes. In amphibians, the equivalent structure is the blastopore. During early embryonic development, the embryonic disc becomes oval shaped, and then pear-shaped with the broad end towards the anterior, and the narrower region projected to the posterior. The primitive streak forms a longitudinal midline structure in the narrower posterior (caudal) region of the developing embryo on its dorsal side. At first formation, the primitive streak extends for half the length of the embryo. In the human embryo, this appears by stage 6, about 17 days.
The primitive streak establishes bilateral symmetry, determines the site of gastrulation, and initiates germ layer formation. To form the primitive streak, mesenchymal stem cells are arranged along the prospective midline, establishing the second embryonic axis, and the site where cells will ingress and migrate during the process of gastrulation and germ layer formation.
The primitive streak extends through this midline and creates the left–right and cranial–caudal body axes. Gastrulation involves the ingression of mesoderm progenitors and their migration to their ultimate position, where they will differentiate into the mesoderm germ layer that, together with endoderm and ectoderm germ layers, will give rise to all the tissues of the adult organism.
The epiblast, a single epithelial layer of the bilaminar embryonic disc, is the source of all embryonic material in amniotes, and some of its cells will give rise to the primitive streak. In amphibians, the equivalent structure is the blastopore. The primitive streak forms a longitudinal midline structure in the narrower caudal (posterior) region of the developing embryo on its dorsal side. At first formation, the primitive streak extends for half the length of the embryo. In the human embryo, this appears by Carnegie stage 6, about 17 days.
Towards the cranial (anterior) end of the disc, the primitive streak expands into an area known as the primitive node which is the organizer for gastrulation. In birds, including the chick, this organizing node is called Hensen's node. In amphibians, where it was first identified, it is known as the Spemann-Mangold organizer.
In the middle of the node is a circular depression termed the primitive pit. The primitive pit extends towards the caudal end in a narrow depression in the primitive streak called the primitive groove (Latin: sulcus primitivus). The groove is created by infolding of epiblastic cells.
Following its appearance and formation of the node, pit, and groove, the streak starts to regress caudally. Around day 20 in the human embryo, the remaining parts of the streak enlarge to produce a midline caudal cell mass termed the tail bud or caudal eminence. Also at that time, the notochord develops cranially from the primitive node. By day 22, the primitive streak has regressed to between 10 and 20% of the embryo's length, and by day 26, has seemingly disappeared.
The chick embryo as a model organism has provided much information about the formation of the primitive streak. In the chick blastula, its formation involves the coordinated movement and re-arrangement of cells in the epiblast. Two counter-rotating flows of cells meet at the posterior end, where the streak forms. There is little movement in the center of these flows, while the greatest movement is observed at the periphery of the vortices. The vortex movements likened to polonaise movement is key for the formation of the primitive streak. Cells overlaying Koller's sickle in the posterior end of the chick embryo move towards the midline, meet and change direction towards the center of the epiblast. Cells from the lateral posterior marginal zone replace those cells that left Koller's Sickle by meeting at the center of this region, changing direction and extending anteriorly. As these cells move and concentrate at the posterior end of the embryo, the streak undergoes a single- to multi-layered epithelial sheet transition that makes it a macroscopically visible structure. Several mechanisms, including active proliferation, oriented cell division, cell-cell intercalation and chemotactic cell movement, have been proposed to explain the nature of the cellular movements required to form the primitive streak.
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Primitive streak AI simulator
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Primitive streak
The primitive streak is a structure that forms in the early embryo in amniotes. In amphibians, the equivalent structure is the blastopore. During early embryonic development, the embryonic disc becomes oval shaped, and then pear-shaped with the broad end towards the anterior, and the narrower region projected to the posterior. The primitive streak forms a longitudinal midline structure in the narrower posterior (caudal) region of the developing embryo on its dorsal side. At first formation, the primitive streak extends for half the length of the embryo. In the human embryo, this appears by stage 6, about 17 days.
The primitive streak establishes bilateral symmetry, determines the site of gastrulation, and initiates germ layer formation. To form the primitive streak, mesenchymal stem cells are arranged along the prospective midline, establishing the second embryonic axis, and the site where cells will ingress and migrate during the process of gastrulation and germ layer formation.
The primitive streak extends through this midline and creates the left–right and cranial–caudal body axes. Gastrulation involves the ingression of mesoderm progenitors and their migration to their ultimate position, where they will differentiate into the mesoderm germ layer that, together with endoderm and ectoderm germ layers, will give rise to all the tissues of the adult organism.
The epiblast, a single epithelial layer of the bilaminar embryonic disc, is the source of all embryonic material in amniotes, and some of its cells will give rise to the primitive streak. In amphibians, the equivalent structure is the blastopore. The primitive streak forms a longitudinal midline structure in the narrower caudal (posterior) region of the developing embryo on its dorsal side. At first formation, the primitive streak extends for half the length of the embryo. In the human embryo, this appears by Carnegie stage 6, about 17 days.
Towards the cranial (anterior) end of the disc, the primitive streak expands into an area known as the primitive node which is the organizer for gastrulation. In birds, including the chick, this organizing node is called Hensen's node. In amphibians, where it was first identified, it is known as the Spemann-Mangold organizer.
In the middle of the node is a circular depression termed the primitive pit. The primitive pit extends towards the caudal end in a narrow depression in the primitive streak called the primitive groove (Latin: sulcus primitivus). The groove is created by infolding of epiblastic cells.
Following its appearance and formation of the node, pit, and groove, the streak starts to regress caudally. Around day 20 in the human embryo, the remaining parts of the streak enlarge to produce a midline caudal cell mass termed the tail bud or caudal eminence. Also at that time, the notochord develops cranially from the primitive node. By day 22, the primitive streak has regressed to between 10 and 20% of the embryo's length, and by day 26, has seemingly disappeared.
The chick embryo as a model organism has provided much information about the formation of the primitive streak. In the chick blastula, its formation involves the coordinated movement and re-arrangement of cells in the epiblast. Two counter-rotating flows of cells meet at the posterior end, where the streak forms. There is little movement in the center of these flows, while the greatest movement is observed at the periphery of the vortices. The vortex movements likened to polonaise movement is key for the formation of the primitive streak. Cells overlaying Koller's sickle in the posterior end of the chick embryo move towards the midline, meet and change direction towards the center of the epiblast. Cells from the lateral posterior marginal zone replace those cells that left Koller's Sickle by meeting at the center of this region, changing direction and extending anteriorly. As these cells move and concentrate at the posterior end of the embryo, the streak undergoes a single- to multi-layered epithelial sheet transition that makes it a macroscopically visible structure. Several mechanisms, including active proliferation, oriented cell division, cell-cell intercalation and chemotactic cell movement, have been proposed to explain the nature of the cellular movements required to form the primitive streak.
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