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Pyrazolidine
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| Names | |||
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| Preferred IUPAC name
Pyrazolidine[1] | |||
| Other names
1,2-Diazolidine
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| Identifiers | |||
3D model (JSmol)
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PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |||
| C3H8N2 | |||
| Molar mass | 72.10902 | ||
| Density | 1.00 g/cm3 (20 °C)[2] | ||
| Melting point | 10 to 12[2] °C (50 to 54 °F; 283 to 285 K) | ||
| Boiling point | 138[2] °C (280 °F; 411 K) | ||
Refractive index (nD)
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1.477[2] | ||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Pyrazolidine is a heterocyclic compound. It is a liquid that is stable in air, but it is hygroscopic.[2]
Preparation
[edit]Pyrazolidine can be produced by cyclization of 1,3-dichloropropane or 1,3-dibromopropane with hydrazine:[2]
- Cl−(CH2)3−Cl + N2H4 → C3H8N2 + 2 HCl
- Br−(CH2)3−Br + N2H4 → C3H8N2 + 2 HBr
See also
[edit]References
[edit]- ^ International Union of Pure and Applied Chemistry (2014). Nomenclature of Organic Chemistry: IUPAC Recommendations and Preferred Names 2013. The Royal Society of Chemistry. p. 142. doi:10.1039/9781849733069. ISBN 978-0-85404-182-4.
- ^ a b c d e f Buhle, Emmett L.; Moore, Alexander M.; Wiselogle, F. Y. (1943). "The Configuration of Tervalent Nitrogen. A Bicyclic Hydrazine Derivative1". Journal of the American Chemical Society. 65 (1). American Chemical Society (ACS): 29–32. doi:10.1021/ja01241a009. ISSN 0002-7863.
| pyrazolones / pyrazolidines | |
|---|---|
| salicylates | |
| acetic acid derivatives and related substances | |
| oxicams | |
| propionic acid derivatives (profens) |
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| n-arylanthranilic acids (fenamates) | |
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Key: underline indicates initially developed first-in-class compound of specific group; #WHO-Essential Medicines; †withdrawn drugs; ‡veterinary use. | |
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