Recent from talks
Quasispecies model
Knowledge base stats:
Talk channels stats:
Members stats:
Quasispecies model
The quasispecies model is a description of the process of the Darwinian evolution of certain self-replicating entities within the framework of physical chemistry. A quasispecies is a large group or "cloud" of related genotypes that exist in an environment of high mutation rate (at stationary state), where a large fraction of offspring are expected to contain one or more mutations relative to the parent. This is in contrast to a species, which from an evolutionary perspective is a more-or-less stable single genotype, most of the offspring of which will be genetically accurate copies.
It is useful mainly in providing a qualitative understanding of the evolutionary processes of self-replicating macromolecules such as RNA or DNA or simple asexual organisms such as bacteria or viruses (see also viral quasispecies), and is helpful in explaining something of the early stages of the origin of life. Quantitative predictions based on this model are difficult because the parameters that serve as its input are impossible to obtain from actual biological systems. The quasispecies model was put forward by Manfred Eigen and Peter Schuster based on initial work done by Eigen.
When evolutionary biologists describe competition between species, they generally assume that each species is a single genotype whose descendants are mostly accurate copies. (Such genotypes are said to have a high reproductive fidelity.) In evolutionary terms, we are interested in the behavior and fitness of that one species or genotype over time.
Some organisms or genotypes, however, may exist in circumstances of low fidelity, where most descendants contain one or more mutations. A group of such genotypes is constantly changing, so discussions of which single genotype is the most fit become meaningless. Importantly, if many closely related genotypes are only one mutation away from each other, then genotypes in the group can mutate back and forth into each other. For example, with one mutation per generation, a child of the sequence AGGT could be AGTT, and a grandchild could be AGGT again. Thus we can envision a "cloud" of related genotypes that is rapidly mutating, with sequences going back and forth among different points in the cloud. Though the proper definition is mathematical, that cloud, roughly speaking, is a quasispecies.[citation needed]
Quasispecies behavior exists for large numbers of individuals existing at a certain (high) range of mutation rates.
In a species, though reproduction may be mostly accurate, periodic mutations will give rise to one or more competing genotypes. If a mutation results in greater replication and survival, the mutant genotype may out-compete the parent genotype and come to dominate the species. Thus, the individual genotypes (or species) may be seen as the units on which selection acts and biologists will often speak of a single genotype's fitness.
In a quasispecies, however, mutations are ubiquitous and so the fitness of an individual genotype becomes meaningless: if one particular mutation generates a boost in reproductive success, it can't amount to much because that genotype's offspring are unlikely to be accurate copies with the same properties. Instead, what matters is the connectedness of the cloud. For example, the sequence AGGT has 12 (3+3+3+3) possible single point mutants AGGA, AGGG, and so on. If 10 of those mutants are viable genotypes that may reproduce (and some of whose offspring or grandchildren may mutate back into AGGT again), we would consider that sequence a well-connected node in the cloud. If instead only two of those mutants are viable, the rest being lethal mutations, then that sequence is poorly connected and most of its descendants will not reproduce. The analog of fitness for a quasispecies is the tendency of nearby relatives within the cloud to be well-connected, meaning that more of the mutant descendants will be viable and give rise to further descendants within the cloud.
When the fitness of a single genotype becomes meaningless because of the high rate of mutations, the cloud as a whole or quasispecies becomes the natural unit of selection.
Hub AI
Quasispecies model AI simulator
(@Quasispecies model_simulator)
Quasispecies model
The quasispecies model is a description of the process of the Darwinian evolution of certain self-replicating entities within the framework of physical chemistry. A quasispecies is a large group or "cloud" of related genotypes that exist in an environment of high mutation rate (at stationary state), where a large fraction of offspring are expected to contain one or more mutations relative to the parent. This is in contrast to a species, which from an evolutionary perspective is a more-or-less stable single genotype, most of the offspring of which will be genetically accurate copies.
It is useful mainly in providing a qualitative understanding of the evolutionary processes of self-replicating macromolecules such as RNA or DNA or simple asexual organisms such as bacteria or viruses (see also viral quasispecies), and is helpful in explaining something of the early stages of the origin of life. Quantitative predictions based on this model are difficult because the parameters that serve as its input are impossible to obtain from actual biological systems. The quasispecies model was put forward by Manfred Eigen and Peter Schuster based on initial work done by Eigen.
When evolutionary biologists describe competition between species, they generally assume that each species is a single genotype whose descendants are mostly accurate copies. (Such genotypes are said to have a high reproductive fidelity.) In evolutionary terms, we are interested in the behavior and fitness of that one species or genotype over time.
Some organisms or genotypes, however, may exist in circumstances of low fidelity, where most descendants contain one or more mutations. A group of such genotypes is constantly changing, so discussions of which single genotype is the most fit become meaningless. Importantly, if many closely related genotypes are only one mutation away from each other, then genotypes in the group can mutate back and forth into each other. For example, with one mutation per generation, a child of the sequence AGGT could be AGTT, and a grandchild could be AGGT again. Thus we can envision a "cloud" of related genotypes that is rapidly mutating, with sequences going back and forth among different points in the cloud. Though the proper definition is mathematical, that cloud, roughly speaking, is a quasispecies.[citation needed]
Quasispecies behavior exists for large numbers of individuals existing at a certain (high) range of mutation rates.
In a species, though reproduction may be mostly accurate, periodic mutations will give rise to one or more competing genotypes. If a mutation results in greater replication and survival, the mutant genotype may out-compete the parent genotype and come to dominate the species. Thus, the individual genotypes (or species) may be seen as the units on which selection acts and biologists will often speak of a single genotype's fitness.
In a quasispecies, however, mutations are ubiquitous and so the fitness of an individual genotype becomes meaningless: if one particular mutation generates a boost in reproductive success, it can't amount to much because that genotype's offspring are unlikely to be accurate copies with the same properties. Instead, what matters is the connectedness of the cloud. For example, the sequence AGGT has 12 (3+3+3+3) possible single point mutants AGGA, AGGG, and so on. If 10 of those mutants are viable genotypes that may reproduce (and some of whose offspring or grandchildren may mutate back into AGGT again), we would consider that sequence a well-connected node in the cloud. If instead only two of those mutants are viable, the rest being lethal mutations, then that sequence is poorly connected and most of its descendants will not reproduce. The analog of fitness for a quasispecies is the tendency of nearby relatives within the cloud to be well-connected, meaning that more of the mutant descendants will be viable and give rise to further descendants within the cloud.
When the fitness of a single genotype becomes meaningless because of the high rate of mutations, the cloud as a whole or quasispecies becomes the natural unit of selection.