In probability theory and mathematical physics, a random matrix is a matrix-valued random variable—that is, a matrix in which some or all of its entries are sampled randomly from a probability distribution. Random matrix theory (RMT) is the study of properties of random matrices, often as they become large. RMT provides techniques like mean-field theory, diagrammatic methods, the cavity method, or the replica method to compute quantities like traces, spectral densities, or scalar products between eigenvectors. Many physical phenomena, such as the spectrum of nuclei of heavy atoms, the thermal conductivity of a lattice, or the emergence of quantum chaos, can be modeled mathematically as problems concerning large, random matrices.

Random matrix theory first gained attention beyond mathematics literature in the context of nuclear physics. Experiments by Enrico Fermi and others demonstrated evidence that individual nucleons cannot be approximated to move independently, leading Niels Bohr to formulate the idea of a compound nucleus. Because there was no knowledge of direct nucleon-nucleon interactions, Eugene Wigner and Leonard Eisenbud approximated that the nuclear Hamiltonian could be modeled as a random matrix. For larger atoms, the distribution of the energy eigenvalues of the Hamiltonian could be computed in order to approximate scattering cross sections by invoking the Wishart distribution.

In nuclear physics, random matrices were introduced by Eugene Wigner to model the nuclei of heavy atoms. Wigner postulated that the spacings between the lines in the spectrum of a heavy atom nucleus should resemble the spacings between the eigenvalues of a random matrix, and should depend only on the symmetry class of the underlying evolution. In solid-state physics, random matrices model the behaviour of large disordered Hamiltonians in the mean-field approximation.

In quantum chaos, the Bohigas–Giannoni–Schmit (BGS) conjecture asserts that the spectral statistics of quantum systems whose classical counterparts exhibit chaotic behaviour are described by random matrix theory.

In quantum optics, transformations described by random unitary matrices are crucial for demonstrating the advantage of quantum over classical computation (see, e.g., the boson sampling model). Moreover, such random unitary transformations can be directly implemented in an optical circuit, by mapping their parameters to optical circuit components (that is beam splitters and phase shifters).

In multivariate statistics, random matrices were introduced by John Wishart, who sought to estimate covariance matrices of large samples. Chernoff-, Bernstein-, and Hoeffding-type inequalities can typically be strengthened when applied to the maximal eigenvalue (i.e. the eigenvalue of largest magnitude) of a finite sum of random Hermitian matrices. Random matrix theory is used to study the spectral properties of random matrices—such as sample covariance matrices—which is of particular interest in high-dimensional statistics. Random matrix theory also saw applications in neural networks and deep learning, with recent work utilizing random matrices to show that hyper-parameter tunings can be cheaply transferred between large neural networks without the need for re-training.

In numerical analysis, random matrices have been used since the work of John von Neumann and Herman Goldstine to describe computation errors in operations such as matrix multiplication. Although random entries are traditional "generic" inputs to an algorithm, the concentration of measure associated with random matrix distributions implies that random matrices will not test large portions of an algorithm's input space.

In number theory, the distribution of zeros of the Riemann zeta function (and other L-functions) is modeled by the distribution of eigenvalues of certain random matrices. The connection was first discovered by Hugh Montgomery and Freeman Dyson. It is connected to the Hilbert–Pólya conjecture.