The region of Palestine, also known as historic Palestine or land of Palestine, is a geographical area in West Asia. It includes the modern states of Israel and Palestine, and some definitions include parts of northwestern Jordan. Other names for the region include Canaan, the Promised Land, the Land of Israel, the Holy Land, and Judea.

The earliest written record referring to Palestine as a geographical region is in the Histories of Herodotus in the 5th century BCE, which calls the area Palaistine, referring to the territory previously held by Philistia, a state that existed in that area from the 12th to the 7th century BCE. The Roman Empire conquered the region in 63 BCE and appointed client kings to rule over it until Rome began directly ruling over the region and established a predominately-Jewish province named "Judaea" in 6 CE. The Roman Empire killed the vast majority of Jews in Judaea to suppress the Bar Kokhba revolt during 132-136 CE; shortly after the revolt, the Romans expelled and enslaved nearly all of the remaining Jews in the historical Judah region centered on Jerusalem, depopulating that area. Roman authorities renamed the province of Judaea to "Syria Palaestina" in c. 135 CE to punish Jews for the Bar Kokhba Revolt and permanently sever ties between Jews and the province. In 390, during the Byzantine period, the region was split into the provinces of Palaestina Prima, Palaestina Secunda, and Palaestina Tertia. Following the Muslim conquest of the Levant in the 630s, the military district of Jund Filastin was established. While Palestine's boundaries have changed throughout history, it has generally comprised the southern portion of the wider Syria or Levant region.

As the birthplace of Judaism and Christianity, Palestine has been a crossroads for religion, culture, commerce, and politics. In the Bronze Age, it was home to Canaanite city-states; and the later Iron Age saw the emergence of Israel and Judah. It has since come under the sway of various empires, including the Neo-Assyrian, the Neo-Babylonian, the Achaemenid Persian, the Macedonian (of Alexander the Great), and the Ptolemaic and Seleucid empires. The brief Hasmonean dynasty ended with its gradual incorporation into the Roman Empire, and later the Byzantine Empire, during which Palestine became a center of Christianity. In the 7th century, Palestine was conquered by the Muslim Rashidun Caliphate, ending Byzantine rule in the region; Rashidun rule was succeeded by the Umayyad, Abbasid, and Fatimid caliphates. Following the collapse of the Kingdom of Jerusalem, which had been established through the Crusades, the population of Palestine became predominantly Muslim. In the 13th century, it became part of the Mamluk Sultanate, and after 1516, spent four centuries as part of the Ottoman Empire.

During World War I, Palestine was occupied by the United Kingdom as part of the Sinai and Palestine campaign. Between 1919 and 1922, the League of Nations created the Mandate for Palestine, which came under British administration as Mandatory Palestine through the 1940s. Tensions between Jews and Arabs escalated into the 1947–1949 Palestine war, which ended with the establishment of Israel on most of the territory, and neighboring Jordan and Egypt controlling the West Bank and the Gaza Strip, respectively. The 1967 Six-Day War saw Israel's occupation of both territories, which has been among the core issues of the ongoing Israeli–Palestinian conflict.

Modern archaeology has identified 12 ancient inscriptions from Egyptian and Assyrian records recording likely cognates of Hebrew Pelesheth. The term "Peleset" (transliterated from hieroglyphs as P-r-s-t) is found in five inscriptions referring to a neighboring people or land starting from c. 1150 BCE during the Twentieth dynasty of Egypt. The first known mention is at the temple at Medinet Habu which refers to the Peleset among those who fought with Egypt in Ramesses III's reign, and the last known is 300 years later on Padiiset's Statue. Seven known Assyrian inscriptions refer to the region of "Palashtu" or "Pilistu", beginning with Adad-nirari III in the Nimrud Slab in c. 800 BCE through to a treaty made by Esarhaddon more than a century later. Neither the Egyptian nor the Assyrian sources provided clear regional boundaries for the term.

The first clear use of the term Palestine to refer to the entire area between Phoenicia and Egypt was in 5th century BCE ancient Greece, when Herodotus wrote in The Histories of a "district of Syria, called Palaistínē" (Ancient Greek: Συρίη ἡ Παλαιστίνη καλεομένη), which included the Judean mountains and the Jordan Rift Valley. Approximately a century later, Aristotle used a similar definition for the region in Meteorology, in which he included the Dead Sea. Later Greek writers such as Polemon and Pausanias also used the term to refer to the same region, which was followed by Roman writers such as Ovid, Tibullus, Pomponius Mela, Pliny the Elder, Dio Chrysostom, Statius, Plutarch as well as Romano-Jewish writers Philo of Alexandria and Josephus.

Many classical-era sources referred to the inland region inhabited by Jews as Judea, distinguishing it from the Philistine coastal area. The Roman Empire conquered the region and in 6 CE established a predominately-Jewish province named "Judaea." The Roman Empire killed the vast majority of Jews in Judaea to suppress the Bar Kokhba Revolt during 132-136 CE; shortly after the revolt, the Romans expelled and enslaved nearly all of the remaining Jews in Judaea, depopulating the region. Roman authorities renamed the province of Judaea to "Syria Palaestina" in c. 135 CE to punish Jews for the Bar Kokhba Revolt and permanently sever ties between Jews and the province. This was the only case where the Roman Empire renamed a province specifically in response to a rebellion. There is circumstantial evidence linking Hadrian with the name change, but the precise date is not certain.

The term is generally accepted to be a cognate of the biblical name Peleshet (פלשת Pəlésheth, usually transliterated as Philistia). The term and its derivates are used more than 250 times in Masoretic-derived versions of the Hebrew Bible, of which 10 uses are in the Torah, with undefined boundaries, and almost 200 of the remaining references are in the Book of Judges and the Books of Samuel. The term is rarely used in the Septuagint, which used a transliteration Land of Phylistieim (Γῆ τῶν Φυλιστιείμ), different from the contemporary Greek place name Palaistínē (Παλαιστίνη). It is also theorized to be the portmanteau of the Greek word for the Philistines and palaistês, which means "wrestler/rival/adversary". This aligns with the Greek practice of punning place names, since the latter is part of the etymological meaning for Israel.