Margarita Wilson Hanks (born Margarita Ibrahimoff; October 26, 1956) is an American actress, singer, and producer. Her film appearances include Volunteers (1985), Sleepless in Seattle (1993), Now and Then (1995), That Thing You Do! (1996), Jingle All the Way (1996), The Story of Us (1999), Runaway Bride (1999), It's Complicated (2009), and Larry Crowne (2011), and she appeared in the television series The Good Wife and Girls. Wilson has also performed on Broadway and produced several films, including My Big Fat Greek Wedding (2002). As a singer-songwriter, Wilson has released the albums AM/FM, Rita Wilson, Bigger Picture, and Halfway to Home. In March 2019, she received a star on the Hollywood Walk of Fame.

Rita Wilson was born Margarita Ibrahimoff on October 26, 1956 in Los Angeles. Her mother, Dorothea Tzigkou (Greek: Δωροθέα Τζίγκου), was Greek, raised in Sotirë near Dropull i Sipërm in Albania, close to the border with Greece. Her father, Hassan Halilov Ibrahimoff (Bulgarian: Хасан Халилов Ибрахимов; 1920–2009), was a Bulgarian Muslim (Pomak) born in Oraio (Breshtene), Greece, close to the border with Bulgaria. Her father's family moved to Bulgaria when he was a child. He moved from Bulgaria to the US in 1949. He converted from Islam to Orthodox Christianity upon his marriage and changed his name to Allan Wilson in 1960, choosing his name after a local street. The family lived in Los Angeles, where Rita Wilson's father worked as a bartender. Wilson was raised in the Greek Orthodox faith. In addition to Bulgarian, her father could speak "Russian, Turkish, Polish, Greek, a little bit of Italian, a little bit of French" according to Wilson's husband Tom Hanks, who said he modeled his portrayal of the character Viktor Navorski in the film The Terminal on his father-in-law.

Wilson's career began with a guest appearance on The Brady Bunch in the 1972 episode "Greg's Triangle," where she played Pat Conway, one of the candidates running against Marcia Brady for head cheerleader. She also twice appeared on M*A*S*H in 1982 as Nurse Lacey as well as the sitcoms Three's Company and Bosom Buddies starring her future husband Tom Hanks, and as Hester Rose Crane, the deceased mother of Frasier Crane on Frasier.

In the 1980s, Wilson attended the London Academy of Music and Dramatic Art in England.

She has appeared in numerous films, including Volunteers, Barbarians at the Gate, The Bonfire of the Vanities, Mixed Nuts, Sleepless in Seattle, Now and Then, That Thing You Do!, Jingle All the Way, Runaway Bride, Invisible Child, The Story of Us, Raise Your Voice, It's Complicated, and Larry Crowne.

On television, she played Susan Borman, wife of astronaut Frank Borman, in the HBO miniseries From the Earth to the Moon. She guest starred in many series, including Curb Your Enthusiasm, Law & Order: Special Victims Unit, and Body of Proof, and had recurring roles on The Good Wife and Girls.

She was instrumental in helping actress-playwright Nia Vardalos get the movie deal for My Big Fat Greek Wedding, which became the highest-grossing independent film of all time and for which she served as a producer. Wilson produced two stage productions of the play as they were developing the film. A sequel, My Big Fat Greek Wedding 2, which Wilson co-produced and in which she had a supporting role, was released in 2016.

Wilson's Greek heritage was honored in 2016 when the Greek Postal Service ELTA commemorated her with a stamp along with four others: filmmaker Costa-Gavras, engineer and entrepreneur Peter Diamandis, journalist George Stephanopoulos, and billionaire businessman John Catsimatidis. In 2008, Wilson produced the film Mamma Mia!, and eight years later its sequel, Mamma Mia! Here We Go Again.