Robert S. Khuzami (Arabic: روبرت خوزمي; born August 2, 1956) was the Deputy U.S. Attorney for the United States Attorney's Office for the Southern District of New York until March 22, 2019. He previously was a United States federal prosecutor and Assistant United States Attorney for the office, and a former director of the Division of Enforcement of the U.S. Securities and Exchange Commission. He was previously a partner at law firm Kirkland & Ellis. and general counsel of Deutsche Bank AG.

Khuzami was born in Brooklyn and grew up in Rochester, New York. His parents were professional ballroom dancers of Lebanese descent and had a dancing school.

He attended Rush-Henrietta Senior High School, graduating in 1974. After taking a few years off after high school, Khuzami enrolled in college, first studying at the State University of New York at Geneseo, then transferring to the University of Rochester where he was elected to Phi Beta Kappa and graduated magna cum laude in 1979. He received a Juris Doctor degree in 1983 from Boston University School of Law. From 1983 to 1984, he was a law clerk for John R. Gibson of the U.S. Court of Appeals for the Eighth Circuit in Kansas City, Missouri and then went to work at Cadwalader, Wickersham & Taft as a litigation associate.

Khuzami was a prosecutor in the U.S. Attorney's Office in Manhattan's Southern District of New York from 1991 to 2002. From 1999 to 2002, he was chief of that office's Securities and Commodities Fraud Task Force, where he prosecuted complex securities and white-collar crime, including insider trading, Ponzi schemes, accounting and financial statement fraud, organized crime infiltration of the securities markets, and initial public offering and investment adviser fraud. Among other cases, the Task Force under Khuzami was responsible for "Operation Uptick," a one-year joint DOJ-FBI-SEC-NASD undercover operation in which a "front" investment advisory business was set up and located in premises that were bugged with court-authorized eavesdropping devices. As a result, 120 persons were arrested on a variety of securities fraud charges in a single day, including 10 members of the Bonanno and Colombo organized crime families, a former New York City police detective, 57 securities brokers, 12 stock promoters, 30 corporate officers, directors and other insiders, two accountants, a hedge fund manager, and others. This was the largest number of defendants ever arrested at one time on securities fraud related charges and one of the largest number ever arrested in a criminal case of any kind.

One of his cases involved Patrick R. Bennett, founder of Bennett Funding Group, who was charged with running a pyramid scheme and cheating 12,000 investors of $600 million. Bennett's first trial, in March 1999, resulted in a hung jury and the judge, Thomas P. Griesa, declared a mistrial. Khuzami announced his intention to continue legal pursuit of Bennett on all counts for which the jury did not reach a decision. A second jury failed to reach a decision on 11 securities and mail fraud charges and a second judge, John S. Martin, Jr., declared a mistrial on the unresolved charges in June 1999. Bennett, who admitted to seven counts of lying to SEC prosecutors but otherwise maintains his innocence, was described by his lawyers as an inept businessman overwhelmed by an expanding company. In a practice then legal, the judge used his discretion to convict Bennett of stock fraud and money laundering. He was not convicted of running a Ponzi scheme, the main charge. Bennett was also ordered to forfeit $109 million, although he filed for bankruptcy in 1996 and was declared indigent and his lawyers were court-appointed. He was sentenced to 22 years, later extended to 30 because his then-wife did not turn over assets to repay investors.

Khuzami was selected by then-U.S. Attorney Mary Jo White to work with Andrew C. McCarthy and Patrick Fitzgerald in the prosecution of the "Blind Sheikh", Omar Abdel-Rahman, a career-changing case. At the time, the largest terrorism trial in U.S. history, ten defendants were convicted of operating an international terrorist organization responsible for the February 1993 World Trade Center bombing and who planned simultaneous bombing attacks on Federal Bureau of Investigation (FBI) New York headquarters, the United Nations and the Lincoln and Holland Tunnels. Khuzami also prosecuted those accused of assassinating Meir Kahane, and plotting the murders of Hosni Mubarak of Egypt and the Secretary General of the United Nations. Khuzami also supervised some of the initial investigation in New York following the September 11, 2001 attacks.

In 2002, Khuzami was hired by Richard H. Walker to work at Deutsche Bank in New York as Global Head of Litigation and Regulatory Investigations, where he oversaw litigation and regulatory investigations. In 2004, he was promoted to serve as General Counsel for the Americas, where he supervised more than 100 lawyers. From 2002 to 2004, he headed their global litigation and regulatory investigations. He stayed at the bank until 2009. Walker, who had met Khuzami at Cadwalader, Wickersham & Taft when Walker was a partner there, later recommended him for the enforcement job at the SEC, a job he had once held himself.

In 2009 Khuzami was appointed by U.S. Securities and Exchange Commission (SEC) Chairman Mary Schapiro to succeed Linda Chatman Thomsen after the SEC had come under public criticism for failing to detect Bernard Madoff's Ponzi scheme. His appointment was controversial because of his employment at Deutsche Bank, a global investment firm which did business with Goldman Sachs. He was portrayed as an outsider by some but had 11 years' experience as a federal prosecutor.