Rome is an American-British historical drama television series created by John Milius, William J. MacDonald, and Bruno Heller. The series is set in the 1st century BC, during Ancient Rome's transition from Republic to Empire. The series features a sprawling cast of characters, many based on real figures from historical records, but the lead protagonists are two soldiers named Lucius Vorenus and Titus Pullo, who find their lives intertwined with key historical events.

An international co-production between the United States, the United Kingdom and Italy, the series was filmed in various locations, but most notably in the Cinecittà studios in Rome, Italy. The show, consisting of two seasons for a total of 22 episodes, aired on HBO, and BBC Two from 28 August 2005 to 25 March 2007, and was later released on DVD and Blu-ray.

Rome received largely positive reviews and had a high number of viewers. It received substantial media attention from the start, becoming a ratings success for HBO and the BBC (although the numbers declined considerably in the second season) and being honoured with numerous awards, including four Emmy Awards, seven Primetime Emmy Awards, and a Visual Effects Society Award. The series ran for two seasons out of the planned five due to high production cost; much of the material for the third and fourth seasons was telescoped into the second season. Accordingly, the series has been praised for high detail of accuracy and scenery of its daily life, including both its Roman and Egyptian language used in the script.

The series primarily chronicles the lives and deeds of the rich, powerful, and historically significant, but it also focuses on the lives, fortunes, families, and acquaintances of two common men: Lucius Vorenus and Titus Pullo, fictionalized versions of a pair of Roman soldiers mentioned in Caesar's Commentarii de Bello Gallico. The fictional Vorenus and Pullo manage to witness and often influence many of the historical events presented in the series, although some dramatic license is taken.

The first season depicts Julius Caesar's civil war of 49 BC against the traditionalist conservative faction in the Roman Senate (the Optimates), his rise to dictatorship over Rome, and his fall, spanning the time from the end of his Gallic Wars (52 BC or 701 ab urbe condita) until his assassination on 15 March 44 BC (the infamous Ides of March). Against the backdrop of these cataclysmic events, we also see the early years of the young Octavian, who is destined to become Augustus, the first Emperor of Rome. The second season chronicles the power struggle between Octavian and Mark Antony following Caesar's assassination, spanning the period from Caesar's death in 44 BC to the suicide of Antony and Cleopatra in 30 B.C. after their defeat at the Battle of Actium.

Thirty-eight actors are credited in the show's opening credits when they appear, with only Kevin McKidd, Ray Stevenson, Polly Walker, Kerry Condon and James Purefoy appearing in every episode.

William J. MacDonald and John Milius pitched the idea to HBO as a miniseries, but the network made it a full-fledged series. In 2002, HBO and the BBC agreed to co-produce the series, committing a US$100–110 million (£62.7 million) budget to the production of twelve 1-hour episodes, with HBO contributing $85 million, and the BBC contributing $15 million. The BBC contributed £800,000 to every episode of Rome in its first season. Rome is the largest co-produced series with the American film market in the BBC's history. The series also marked the first series on which HBO and the BBC worked together as co-producers, although the two companies had worked together in other roles in earlier series, including Band of Brothers and The Gathering Storm.

Tranter from the BBC has said this about the development of Rome: "It felt like something that could have been developed by us, and HBO felt like natural partners for the BBC". On 20 April 2006, Carolyn Strauss, president of HBO announced the development of a second season for Rome.