Roosevelt Avenue and Greenpoint Avenue are main thoroughfares in the New York City boroughs of Queens and Brooklyn. Roosevelt Avenue begins at 48th Street and Queens Boulevard in the neighborhood of Sunnyside. West of Queens Boulevard, the road is named Greenpoint Avenue and continues through Sunnyside and Long Island City across the Greenpoint Avenue Bridge into Brooklyn, terminating at WNYC Transmitter Park on the East River in the neighborhood of Greenpoint. Roosevelt Avenue goes through Woodside, Jackson Heights, Elmhurst, Corona, Flushing Meadows–Corona Park, Willets Point, and Flushing. In Flushing, Roosevelt Avenue ends at 156th Street and Northern Boulevard.

Greenpoint Avenue was first laid out in 1853 by the Green-Point and Flushing Plank Road Company, who projected a road from the ferry at Greenpoint on a somewhat direct course to Flushing. Upon encountering resistance from local farmers, their road ended at Calvary Cemetery, and was first used in 1854. Roosevelt Avenue is named after US Presidents Theodore Roosevelt and Franklin D. Roosevelt.

Roosevelt Avenue was nationally recognized for its cuisine when Good Magazine named it one of "America's Tastiest Streets". It’s also well known for its diversity of cultural representation, ranging from Indian to Latin American, while in the 2020s, Downtown Flushing is undergoing rapid gentrification by Chinese transnational entities. More than three hundred languages are spoken along the street, and the neighborhoods it passes through are described as the most ethnically diverse in the world. Roosevelt Avenue is a known area for street prostitution.

Structures along the avenues include Eberhard Faber Pencil Factory on the western end of Greenpoint Avenue and the Newtown Creek Wastewater Treatment Plant just west of the Greenpoint Avenue Bridge. Citi Field, the home ballpark of the New York Mets of Major League Baseball (MLB), is located on the intersection of Roosevelt Avenue and Seaver Way (formerly 126th Street) in Flushing Meadows-Corona Park. Shea Stadium, the former home of the Mets and the New York Jets of the American Football League (AFL) and the National Football League (NFL), was located in the Citi Field parking lots. Etihad Park, the future home stadium of New York City FC of Major League Soccer (MLS), is currently under construction adjacent to Citi Field in Willets Point and is scheduled to open in 2027. The eastern end of Roosevelt Avenue contains the Protestant Reformed Dutch Church of Flushing.

The corridor is served by the following subway lines:

The following bus routes serve Roosevelt:

The B24 is the only bus route to serve Greenpoint Avenue, from 47th Street to West Street (Greenpoint), and from Manhattan Avenue to 48th Street (Williamsburg). Greenpoint service runs east on the avenue non-stop from Franklin Street to Manhattan Avenue before switching to Williamsburg. The one-way section from Review Avenue to Starr Avenue requires westbound buses to divert around Van Dam Street.