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SDZ SER-082
SER-082, or SDZ SER-082, is a selective serotonin 5-HT2B and 5-HT2C receptor antagonist or weak partial agonist with an ergoline-like structure which is used in scientific research. It shows similar affinity for the serotonin 5-HT2B and 5-HT2C receptors and has ~40-fold higher affinity for the serotonin 5-HT2C receptor over the closely related serotonin 5-HT2A receptor.
It has been used in animal studies into the behavioural effects of the different 5-HT2 subtypes, and how they influence the effects of other drugs such as cocaine. The drug has been found to have no effect on anxiety in multiple paradigms in rodents. In contrast to other serotonin 5-HT2C receptor antagonists, SER-082 does not produce hyperlocomotion in rodents, and instead can produce hypolocomotion at high doses that is independent of the serotonin 5-HT2C receptor.
It fails to block the effects of serotonergic psychedelics in multiple behavioral paradigms, in contrast to serotonin 5-HT2A receptor antagonists. However, the hypolocomotion induced by high doses of the phenethylamine psychedelic DOI can be attenuated by SER-082. Conversely, the drug was ineffective against the hypolocomotion induced by the tryptamine psychedelic 5-MeO-DMT, whereas the serotonin 5-HT1A receptor antagonist WAY-100635 was effective.
SDZ SER-082
SER-082, or SDZ SER-082, is a selective serotonin 5-HT2B and 5-HT2C receptor antagonist or weak partial agonist with an ergoline-like structure which is used in scientific research. It shows similar affinity for the serotonin 5-HT2B and 5-HT2C receptors and has ~40-fold higher affinity for the serotonin 5-HT2C receptor over the closely related serotonin 5-HT2A receptor.
It has been used in animal studies into the behavioural effects of the different 5-HT2 subtypes, and how they influence the effects of other drugs such as cocaine. The drug has been found to have no effect on anxiety in multiple paradigms in rodents. In contrast to other serotonin 5-HT2C receptor antagonists, SER-082 does not produce hyperlocomotion in rodents, and instead can produce hypolocomotion at high doses that is independent of the serotonin 5-HT2C receptor.
It fails to block the effects of serotonergic psychedelics in multiple behavioral paradigms, in contrast to serotonin 5-HT2A receptor antagonists. However, the hypolocomotion induced by high doses of the phenethylamine psychedelic DOI can be attenuated by SER-082. Conversely, the drug was ineffective against the hypolocomotion induced by the tryptamine psychedelic 5-MeO-DMT, whereas the serotonin 5-HT1A receptor antagonist WAY-100635 was effective.
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