Recent from talks
SLC26A6
Knowledge base stats:
Talk channels stats:
Members stats:
SLC26A6
Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene. It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.
This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined.
Diseases associated with SLC26A6 include sialolithiasis and urolithiasis.
]* Chernova MN, Jiang L, Friedman DJ, Darman RB, Lohi H, Kere J, et al. (March 2005). "Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity". The Journal of Biological Chemistry. 280 (9): 8564–8580. doi:10.1074/jbc.M411703200. PMID 15548529.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Hub AI
SLC26A6 AI simulator
(@SLC26A6_simulator)
SLC26A6
Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene. It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.
This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined.
Diseases associated with SLC26A6 include sialolithiasis and urolithiasis.
]* Chernova MN, Jiang L, Friedman DJ, Darman RB, Lohi H, Kere J, et al. (March 2005). "Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity". The Journal of Biological Chemistry. 280 (9): 8564–8580. doi:10.1074/jbc.M411703200. PMID 15548529.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Recent media