Safsaf (Arabic: صفصاف Ṣafṣāf, "weeping willow") was a Palestinian village 9 kilometres northwest of Safed, present-day Israel. Its villagers fled to Lebanon after the Safsaf massacre in October 1948, during the 1948 Arab–Israeli War.

The village was called Safsofa in Roman times.

According to Yaqut, it was harried in 950 CE by the Hamdanid ruler of Aleppo, Sayf al-Dawla.

In the early sixteenth century CE, Safsaf was incorporated into the Ottoman Empire, and by the 1596 tax records, it was a village in the nahiyah ("subdistrict") of Jira, part of Sanjak Safad. It had a population of 25 households, an estimated 138 persons, all Muslim. The villagers paid a fixed tax rate of 25% on several agricultural items, including wheat, barley, olives and fruits, as well as other types of produce, such as beehives and goats; a total of 3,714 akçe. A quarter of the revenue went to a waqf (religious endowment).

In 1838 Safsaf was noted as a village in the Safad district, while in 1875 Victor Guérin described it as a village with fifteen Muslim families.

In 1881 the PEF's Survey of Western Palestine described Safsaf as a small village situated on a plain, with a population of about 100. They also noted that "ornamented stones of a preexisting public building" had been built into the doorway of the village mosque. The villagers cultivated olive and fig trees and vineyards.

A population list from about 1887 showed Safsaf to have about 740 inhabitants, all Muslim. At this time it was part of Beirut vilayet.

Safsaf became a part of the British Mandate in 1922. During this time, the village lay on the eastern side of the Safad-Tarshiha highway and extended in a northeast–southwest direction. All the residents of Safsaf were Muslims. A mosque and several shops were located in the village center, and an elementary school was established during this period. Agriculture was the main economic activity, and it was both irrigated from springs and rainfed. Fruits and olives were cultivated on the land north of the village.