Sailor Moon Crystal, known in Japan as Pretty Guardian Sailor Moon Crystal (Japanese: 美少女戦士セーラームーンCrystal（クリスタル）, Hepburn: Bishōjo Senshi Sērā Mūn Kurisutaru), is a Japanese anime series based on the shōjo manga series Sailor Moon written and illustrated by Naoko Takeuchi, produced in commemoration of the original series' 20th anniversary. Produced by Toei Animation and directed by Munehisa Sakai (Seasons 1 and 2) and Chiaki Kon (Season 3), the series was streamed worldwide on Niconico from July 5, 2014, to July 18, 2015. Season 1 and 2's episodes were released twice a month. Instead of remaking the 1990s anime series preceding it, Toei Animation produced Crystal as a reboot of Sailor Moon and as a more faithful adaptation of the original manga by omitting much of the original material from the first series. Set in Tokyo in the 2010s, the story focuses on Usagi Tsukino, who is a young girl that obtains the power to become the titular character. Other Sailor Guardians join her in the search for Princess Serenity and the Silver Crystal.

The first episode had an advanced screening on June 30, 2014. In May 2014, Viz Media licensed Crystal for an English-language release in North America, simulcasting the series on Neon Alley and Hulu to coincide with the worldwide streaming. Crunchyroll also simulcast the series in a separate contract with Toei Animation. Viz premiered the first episode as part of their "Sailor Moon Day" celebration at the Anime Expo Convention in Los Angeles.

The third season, based on the Infinity arc of the manga, premiered on April 4, 2016, and concluded on June 27, 2016.

A sequel two-part film, Pretty Guardian Sailor Moon Eternal The Movie, based on the Dream arc of the manga, was released in 2021, with the first film released on January 8 and the second on February 11, followed by another sequel two-part film, Pretty Guardian Sailor Moon Cosmos The Movie, based on the Stars arc of the manga, which was released on June 9 and 30, 2023.

Set in Tokyo in the 2010s, Usagi Tsukino, a fourteen-year-old middle school student, meets Luna, a talking black cat that tells her that she is Sailor Moon, a Sailor Guardian destined to fight a group of villains called the Dark Kingdom. Luna also instructs Sailor Moon to find her four fellow Sailor Guardians, the long-lost Princess of an ancestral kingdom on the Moon, and a legendary artifact of supreme power known as the Silver Crystal. On her journey, Sailor Moon meets her fellow Guardians Sailor Mercury (Ami Mizuno), Sailor Mars (Rei Hino), Sailor Jupiter (Makoto Kino), Sailor Venus (Minako Aino), and a mysterious masked man called Tuxedo Mask (Mamoru Chiba), to whom Usagi is attracted. Later, Usagi and the Sailor Guardians discover that in their previous lives they were members of an ancient Moon Kingdom in a period of time called the Silver Millennium. The Dark Kingdom waged war against them, resulting in the destruction of the Moon Kingdom. It turns out that Sailor Moon herself is Serenity, the Princess of the Moon Kingdom, and that she alone has the power to make the Silver Crystal appear and to use its incredible mystical powers to overcome the forces of evil.

Meanwhile, Tuxedo Mask is revealed to be Endymion, the first crown prince of the Earth and Serenity's lover in his previous life. After defeating the Four Kings of Heaven (who turn out to have been Prince Endymion's loyal knights in the past) and killing their leader Queen Beryl, the Sailor Guardians confront a brainwashed Endymion and the ruler of the Dark Kingdom — Queen Metaria. To prevent Queen Metaria from spreading darkness all over the Earth, the Guardians sacrifice their lives. Using the power of the Silver Crystal, Sailor Moon destroys Queen Metaria and reunites with her four friends upon returning them to life.

After Sailor Moon restores the Earth to normal and prepares to live a normal life again with Mamoru and her friends, a little girl falls from the sky, claiming to have the same name as Usagi, but nicknamed as "Chibiusa" by Usagi and the others. A group of villains called the Black Moon Clan, led by Prince Demande, initiate a series of operations which lead to the abductions of Sailors Mars, Mercury, and Jupiter while looking for Chibiusa and the Silver Crystal. Chibiusa is revealed to be Sailor Moon's and Tuxedo Mask's daughter from a distant future that has been decimated by the Clan, and is searching for Sailor Moon and the Silver Crystal in order to save her mother. Sailor Moon and her friends accompany Chibiusa to the future, and they meet the Guardian of Spacetime and Chibiusa's friend, Sailor Pluto.

After being captured herself, Sailor Moon then rescues Mars, Mercury, and Jupiter, and they escape from the planet Nemesis, the Black Moon Clan's headquarters. Chibiusa is manipulated by Prince Demande's advisor and the true mastermind of the Black Moon Clan, Death Phantom, and transforms into Black Lady, who brainwashes Tuxedo Mask as well. During an intense battle, Demande manages to obtain the Silver Crystals of the past and the future and tries to bring them together to destroy the universe in a time paradox. Sailor Pluto stops time to prevent this from happening, leading to her own death. Black Lady is shocked to see her friend die and reverts to her true self, transforming into Sailor Chibi Moon. Demande dies protecting Sailor Moon from Death Phantom, but the latter is destroyed by the combined powers of Sailor Moon and Sailor Chibi Moon. Neo-Queen Serenity, the future incarnation of Sailor Moon who had also awakened, gives the four Sailor Guardians new Planet Powers and gives Sailor Moon a new brooch, as her old one was destroyed defeating Death Phantom. Sailor Moon and her friends say goodbye to their future selves and return to the past. Chibiusa stays in the future, but returns to the past shortly afterwards to train as a Sailor Guardian.