Salvation Run is a seven-issue 2007-2008 DC Comics limited series which was designed to tie into the company's major event series Final Crisis in 2008. The series involves a large group of supervillains being exiled to the planet Cygnus 4019, also known as Salvation, where they are given no support to survive.

The concept of Salvation Run is adapted in the second season of Peacemaker, where the planet Salvation is depicted as a prison located in another dimension.

The series, which is based on a pitch from writers George R. R. Martin and John Jos. Miller, follows a world where various supervillains are captured by the Suicide Squad and imprisoned on the distant planet of Cygnus 4019. The story features the villains splitting into alliances and either attempting to escape the planet, known as "Salvation", or choosing to rule over it. Bill Willingham started as writer, but had to hand the project over to Lilah Sturges after only three issues due to illness. The first issue was released in November 2007.

Major characters in Salvation Run include Lex Luthor, the Joker, the Rogues (Heat Wave, Captain Cold, Weather Wizard, Abra Kadabra and Mirror Master), and other morally ambiguous heroes such as Scandal Savage and Catwoman. Tie-ins to the series were released in Countdown to Final Crisis, Outsiders, Checkmate, Catwoman, and Justice League of America.

A compiled paperback version of Salvation Run was released on September 24, 2008.

Following Black Adam's rampage in World War III, the Amazonian attack on the United States, the murder of the Flash (Bart Allen), and the Injustice League's attack upon the wedding of Green Arrow and Black Canary, a government-sponsored secret program is put in place to combat the growing metahuman threat. Initiated by the President and executed by Amanda Waller of Checkmate and the Suicide Squad, the purpose of the program is to capture supervillains and exile them to the distant planet Cygnus 4019, also known as Salvation, somewhere in Cygnus X-1 via a Boom Tube. Several Suicide Squad members, including Bane and Deadshot, are sent to Salvation once they are no longer needed. According to Rick Flag Jr., the prisoners are not given any supplies or equipment for their survival, as that would make the government responsible for them. Once they are off-world, they are no longer Earth's responsibility. Cygnus 4019 was intended to be peaceful, but was turned into a "training planet" for the New Gods of Apokolips, overseen by DeSaad.

Having arrived on Cygnus first, the Rogues (Abra Kadabra, Captain Cold, Heat Wave, Mirror Master, and Weather Wizard) are the first to find out that the Cygnus is seemingly designed to kill any visitors. Kadabra deciphers the language of the local pygmies and learns of the "Safe Zone", a safe district. During their journey, they hear a second Boom Tube arrive and decide to go back. Out of the Boom Tubes come Black Spider, Cheetah, Clayface, Effigy, Girder, Hammer and Sickle, a Hyena, Joker, Kid Karnevil, Killer Croc, Killer Frost, Mammoth, Mr. Freeze, Mister Terrible, Phobia, Psimon, Rock, Shimmer, Shrapnel, Sonar, Tapeworm, and Tremor. For a short time, they attempt to assert leadership over the second group.

The Body Doubles, Hellhound, Iron Cross, Manticore, Meanstreak, Metallo, Rag Doll, Skorpio, and Tar Pit battle wild robotic beasts, during which Hellhound is wounded. Despite their plans to leave him to die, the other villains bring Hellhound along only to feed him to lion-lizards. Back at camp, Kid Karnevil tells the Joker that he has looked up to him and plans to surpass him by slaying him when he least suspects it. Psimon orates to the entire group that he has figured out a way for them to survive as a society, but it is rejected and he is killed by the Joker. Meanwhile, Rick Flag Jr. transports Bane, Chemo, Lex Luthor, Catwoman, the third Blockbuster, and Deadshot to Cygnus, seeing no further use for Bane and Deadshot.