Samuel Houser is born in London, England. Details about his early childhood are scarce, but his upbringing undoubtedly influenced his later creative endeavors. His exposure to British culture and media would later inform the distinct satirical tone and character-driven narratives prevalent in Rockstar's games.

Houser began his career in the music industry. Before joining the world of video games, he worked for BMG Interactive, a division of the Bertelsmann Music Group. This experience likely provided him with valuable insight into the creative industries and the importance of marketing and brand building, skills he would later utilize at Rockstar.