Scissor Sisters are an American pop rock band formed in 2000. The band's current line-up consists of Jake Shears (vocals), Babydaddy (various instruments) and Del Marquis (guitar, bass). Former members include vocalist Ana Matronic and original drummer Paddy Boom. Scissor Sisters incorporate diverse styles in their music, but tend to sway towards pop rock, glam rock, nu-disco, and electroclash. Forged in the "gay nightlife scene of New York", the band took its name from the female same-sex sexual activity of tribadism.

The band came to prominence following the release of their Grammy-nominated and chart-topping disco version of "Comfortably Numb" and subsequent debut album Scissor Sisters (2004). The album was a success, particularly in the UK where it reached number one, was the best-selling album of 2004, was later certified nine-times platinum by the BPI, and earned them three BRIT Awards in 2005. All five of its singles reached positions within the top 20 of the UK Singles Chart while "Filthy/Gorgeous" scored the band their first number one on Billboard's Hot Dance Club Songs, despite the album's limited success in their native US.

The album continued its success in countries around Europe, in Australia and in Canada before the release of the band's second studio album Ta-Dah (2006), their second consecutive UK number one album which produced their first UK number one single "I Don't Feel Like Dancin'". Their third studio album Night Work (2010) displayed a shift towards a more club-oriented sound, charting at number two on the UK Albums Chart, number one on Billboard's Top Independent Albums chart and in the top 10 of several international territories. The band released their fourth studio album Magic Hour in May 2012.

Scissor Sisters has performed around the world and have become recognized for their controversial and transgressive live performances. They also collaborated with a number of other well-known pop musicians, including Elton John and Kylie Minogue; these particular collaborations have been received positively by both critics and other notable figures. In 2004, Bono, lead vocalist of rock band U2, described Scissor Sisters as "the best pop group in the world". They also collaborated with Global Cool in 2007 on one of their green lifestyle campaigns.

Originally named Dead Lesbian and the Fibrillating Scissor Sisters, the final two words being derived from the lesbian sexual act of tribadism, the band was founded in 2000 after friends Jason "Jake Shears" Sellards and Scott "Babydaddy" Hoffman (who had met in 1999 in Lexington, Kentucky) both moved to New York City, enjoying its open and gay-friendly ethos. They began producing music together, with Babydaddy composing music and Shears writing lyrics. The duo released a couple of singles to little success and began appearing at underground clubs on New York's Lower East Side. On a trip to Disneyland, the pair met Ana "Matronic" Lynch at a screening of Michael Jackson's Captain EO. During a subsequent teacup ride, they discovered that they had a lot in common. Shears later remarked, "I really thought she was a freak but when I started singing "Another Part of Me" she showed me the best moonwalk I've ever seen."

Ana Matronic ran a weekly cabaret event known as Knock Off at a club called the Slipper Room in New York, where she liked to hire eccentric and alternative acts; one reporter described it as a place that "served up a racy, multigender revue of kitsch," and that a performer dressed as a giant vulva "enfolded me with her labia while singing "Lick Me in My Wet Spot" to the tune of "Hit Me With Your Best Shot"." Matronic invited the pair to appear at Knock Off, which they did on September 21, 2001. Shears dressed as his character "Jason the Amazing Back-Alley Late Term Abortion" whilst Matronic, dressed as a reject from Andy Warhol's Factory, joined the pair on stage and sang. Shears and Babydaddy felt she was very effective and asked her to join the band on a permanent basis, to which she agreed.

The trio then began appearing at other clubs, dropping the word "Fibrillating" from their name. They primarily played electroclash, which was popular at the time in the underground club scene of New York with bands like Peaches and Chicks on Speed. They were soon joined by Derek "Del Marquis" Gruen on lead guitar, who had known Shears from when they both worked at the IC Guys club where Shears had been a stripper. They were joined by a fifth member, Patrick "Paddy Boom" Seacor, on drums who (being heterosexual) felt the need to explain to his mother that "it's not a gay band... there [are] gay members, but it doesn't matter. It's about the music and about performance."

In 2002, the band signed with a small New York record company called A Touch of Class for a two-single deal. Their first single "Electrobix" dealt with gay men's obsessions with working out but proved to be less popular than its B-side, a cover version of Pink Floyd's progressive rock classic "Comfortably Numb". Matronic commented, "It's one of those songs that people were either gonna love or hate, and that's really, really powerful, because it basically means you're evoking a reaction in everyone. The first time I heard it, I thought that if it doesn't make us famous, it'll make us infamous because somebody will shoot us!" Their version of "Comfortably Numb" became a hit in many dance clubs and, after sending Pink Floyd themselves a copy, the Scissor Sisters received positive remarks from the song's original writers Roger Waters and David Gilmour. The song proved to be particularly popular in the UK, where various record labels soon took an interest in the band. In 2003, they decided they would tour Europe where they believed audiences would be more receptive to them and their music than their native US.