Scorpio is the name of several fictional characters appearing in American comic books published by Marvel Comics. Most of the characters to use the Scorpio identity have been supervillains affiliated with the Zodiac criminal cartel, and in this context were enemies of the Avengers and other superheroes.

Jake Fury first appeared in Strange Tales #159 (Aug. 1967), and was created by Jim Steranko. He also appeared in Sgt. Fury and his Howling Commandos #68-69 (July–Aug. 1969).

The character subsequently appeared as Scorpio in Nick Fury, Agent of S.H.I.E.L.D. #1 (June 1968), #5 (Oct. 1968), The Avengers #72 (Jan. 1970), The Defenders #46 (April 1977), #48-49 (June–July 1977), #50 (Aug. 1977), West Coast Avengers vol. 2 Annual #1 (1986), West Coast Avengers vol. 2 #26-28 (Nov. 1987-January 1988), Wolverine/Nick Fury: The Scorpio Connection (1989), Fury #1 (May 1994), and Fury of S.H.I.E.L.D. #4 (July 1995).

Jacob Fury received an entry in the Official Handbook of the Marvel Universe Deluxe Edition #17.

Jacob "Jake" Fury was born in New York City. As a young man, he came to resent his brother Nick Fury. As the original Scorpio, he operated as a spy, terrorist, and criminal. Nick later went undercover as Scorpio and took his brother's place in the organization Zodiac. Scorpio constructed a set of android Zodiac members to serve him in his base at Belleville, New Jersey. However, his plan was thwarted by the Defenders and he committed suicide through self-inflicted gunshot wound in despair.

In the series Secret Warriors, it is revealed that the Scorpio who died was a clone of Jake Fury created by ancient technology that was the predecessor to the Life Model Decoy androids. The real Jake had been undercover within Hydra to help bring about the organization's destruction.

Scorpio was later revived in an android body by the Zodiac Key from which he drew his power. The real Jacques LaPoint became the second Scorpio and led the Zodiac until Jake (in his second android body) killed him. Impersonating LaPoint, Fury leads eleven other Zodiac-themed androids to kill and replace the rest of the human Zodiac members, and takes over the organization's criminal operations. Scorpio and the other androids are deactivated after being transported to the Zodiac Key's dimension of origin during a battle with the West Coast Avengers.

Another Scorpio was the leader of Ecliptic's Zodiac team who fought Alpha Flight and was later massacred by Malcolm Colcord's Weapon X team.