Scream is a supervillain appearing in American comic books published by Marvel Comics. The Scream symbiote has appeared in Spider-Man comics, as one of five symbiote spawns created simultaneously and has had four different types.

Scream first appeared in Venom: Lethal Protector #4 (May 1993), and was created by David Michelinie and Ron Lim.

The Scream symbiote was one of the five symbiotes that were forcefully spawned from the original Venom symbiote, and was their unofficial Californian leader. Donna Diego was a volunteer for the Life Foundation, a survivalist group within the American government preparing both for the mutually assured destruction fallout of the Cold War and to provide a comfortable life for wealthy clients after the impending nuclear holocaust. Carlton Drake was experimenting with symbiotes in the hopes of creating so-called 'super-cops' to watch over the imagined fallout shelter utopia, and Donna was picked from the security force made up of police, soldiers and mercenaries. During Scream's first public appearance, she encountered Spider-Man while terrorizing a shopping mall near Salinas, California. Quickly bested by the more experienced fighter, Scream escaped in a hovercraft which returned to the Life Foundation's base. Unknown to her, Spider-Man had hitched a ride on that same hovercraft. Once Spider-Man helped Eddie Brock escape, Scream and the other guardian symbiotes, Lasher, Phage, Riot and Agony, then tangled with Spider-Man and Venom, but Venom turned an accelerated aging device on the five. The age-accelerating machine appeared to make the symbiotes age to dust before the Life Foundation blew up the base.

It was later revealed that Scream and her "siblings" survived, as the Life Foundation was able to save them and their symbiotes. For unknown reasons the guardians had a falling out with their employers and were now fugitives on the run. Scream led the others to New York City in search of Venom, hoping to help teach the five how to control their symbiotes, but Venom wanted nothing to do with them and battled Scream. When Venom disappeared, Scream attempted to enlist the Scarlet Spider to help find Venom. When Scarlet Spider refused, Scream experienced a psychotic break and began a rampage in Times Square. Humiliated when Venom ripped pieces of her symbiote off her and narrowly saved by the Scarlet Spider, Scream disappeared again.

Undiscouraged, Scream rounded up her "siblings" and broke Brock out of prison, kidnapping and imprisoning Brock in a Chicago warehouse. She once again asked for Brock's help in learning to communicate with the symbiotes. Brock once again refused and tried to kill them all, even without the Venom symbiote as back up. Brock escaped, and soon after the "sibling" symbiotes were murdered, one by one. Scream led them to believe that Brock was the killer, while in fact, it had been her the entire time. She had come to the conclusion that all symbiotes are evil, and those that bonded with symbiotes deserved to die. It was revealed that Donna was mentally ill and had been hearing voices long before she was the Scream symbiote's host. Brock managed to re-bond with the Venom symbiote before Scream could go for the kill. While unable to prevent her from murdering every other symbiotes' host, Venom was nevertheless able to beat her in combat yet again and Scream was taken in by the authorities.

Following the symbiote invasion of Earth, Donna was one of the few remaining symbiotes on Earth. Seeking to redeem herself for her crimes, she busied herself tracking down and helping benevolent symbiotic survivors. After her companions began dying mysteriously, Donna tracked Xenophage, a huge alien that devours both symbiotes and their hosts' brains. Donna assisted Venom in slaying the Xenophage but was gravely injured.

After her recovery, Scream sought out the Xenophage's hidden ship to help her track down more symbiotic survivors. The ship transported her and others (including Venom and Wolverine) into another dimension where Scream gets nearly killed once again by the villainous mutants Dirtnap and Chimera. Upon her successful return to Earth, she disappeared, presumably to continue her search for the few remaining symbiotes.

Scream appeared in two panels of the Marvel Super Hero Island Adventures comic giveaway from 1999, as she is shown to be a member of the Sinister Syndicate. She is referred to as Scream in the comics for the first time. Donna's family name Diego is first established (many years after her first appearance as a character in the Marvel Universe) via files where she is quoted as being an "enemy combatant" to the Initiative's forces.