The screw is a mechanism that converts rotational motion to linear motion, and a torque (rotational force) to a linear force. It is one of the six classical simple machines. The most common form consists of a cylindrical shaft with helical grooves or ridges called threads around the outside. The screw passes through a hole in another object or medium, with threads on the inside of the hole that mesh with the screw's threads. When the shaft of the screw is rotated relative to the stationary threads, the screw moves along its axis relative to the medium surrounding it; for example rotating a wood screw forces it into wood. In screw mechanisms, either the screw shaft can rotate through a threaded hole in a stationary object, or a threaded collar such as a nut can rotate around a stationary screw shaft. Geometrically, a screw can be viewed as a narrow inclined plane wrapped around a cylinder.

Like the other simple machines a screw can amplify force; a small rotational force (torque) on the shaft can exert a large axial force on a load. The smaller the pitch (the distance between the screw's threads), the greater the mechanical advantage (the ratio of output to input force). Screws are widely used in threaded fasteners to hold objects together, and in devices such as screw tops for containers, vises, screw jacks and screw presses.

Other mechanisms that use the same principle, also called screws, do not necessarily have a shaft or threads. For example, a corkscrew is a helix-shaped rod with a sharp point, and an Archimedes' screw is a water pump that uses a rotating helical chamber to move water uphill. The common principle of all screws is that a rotating helix can cause linear motion.

The screw was one of the last of the simple machines to be invented. It first appeared in Mesopotamia during the Neo-Assyrian period (911-609) BC, and then later appeared in Ancient Egypt and Ancient Greece.

Records indicate that the water screw, or screw pump, was first used in Ancient Egypt, some time before the Greek philosopher Archimedes described the Archimedes screw water pump around 234 BC. Archimedes wrote the earliest theoretical study of the screw as a machine, and is considered to have introduced the screw in Ancient Greece. By the first century BC, the screw was used in the form of the screw press and the Archimedes' screw.

Greek philosophers defined the screw as one of the simple machines and could calculate its (ideal) mechanical advantage. For example, Heron of Alexandria (52 AD) listed the screw as one of the five mechanisms that could "set a load in motion", defined it as an inclined plane wrapped around a cylinder, and described its fabrication and uses, including describing a tap for cutting female screw threads.

Because their complicated helical shape had to be laboriously cut by hand, screws were only used as linkages in a few machines in the ancient world. Screw fasteners only began to be used in the 15th century in clocks, after screw-cutting lathes were developed. The screw was also apparently applied to drilling and moving materials (besides water) around this time, when images of augers and drills began to appear in European paintings. The complete dynamic theory of simple machines, including the screw, was worked out by Italian scientist Galileo Galilei in 1600 in Le Meccaniche ("On Mechanics").

The fineness or coarseness of a screw's threads are defined by two closely related quantities: