Selina Kyle, nicknamed "Cat", is a fictional character on the Fox TV series Gotham. Based on the DC Comics character of the same name who goes on to become Catwoman, Selina is a morally ambiguous street thief who becomes an ally and later love interest to Bruce Wayne, the orphaned son of Thomas and Martha Wayne. Camren Bicondova portrays Selina Kyle for the majority of Gotham's run, but is replaced by Lili Simmons as an adult in the series finale.

"The main word that I can think of to characterize Selina is that she's just surviving. She's very mischievous and very challenging to play at times, because she feels emotions but she hides them. I realized that she isn't just a street thief and a survivor; she's actually a normal girl."

Gotham depicts the origins of Batman, with the series starting with the murder of Bruce Wayne's parents, as well as that of notable allies and foes such as James Gordon, Alfred Pennyworth, Lucius Fox, Leslie Thompkins, Penguin, Riddler, Poison Ivy and The Joker. Catwoman has been considered a morally ambiguous character, initially being counted as one of Batman's foes but becoming an occasional ally in later comic storylines, developing an iconic love–hate relationship, as she is also Batman's most enduring love interest.

Actress and dancer Camren Bicondova was cast to portray the teenaged Selina. Bicondova auditioned for a random role named "Lucy" and did not find out what the real role was until after she was selected. While she took inspiration from previous Catwoman actresses Michelle Pfeiffer, Anne Hathaway and others, Bicondova wanted to portray a side of Selina Kyle not seen before, focusing on her past. As the series finale jumped ten years into the future from the rest of the series, Bicondova did not feel comfortable portraying her character as an adult, and at her request, an older actress was chosen to portray the adult Selina Kyle. Warner Bros. Television cast Lili Simmons in the role, with Simmons and Bicondova collaborating closely on the adult Selina's characterization.

Selina Kyle is introduced as a 13-year-old street orphan and skilled thief. In the pilot episode, she personally witnesses the murders of Thomas and Martha Wayne. She forms a tenuous alliance with GCPD Detective Jim Gordon after he saves her from kidnappers working for the Dollmaker. She promises to help him solve the Wayne murders if he helps her get out of trouble with the law. Gordon has her temporarily housed at Wayne Manor, which leads to her befriending the Waynes' son, Bruce. She saves him from a gang of hired killers and gives him his first kiss. She also helps Bruce find Reggie Payne, the man who stabbed Bruce's butler Alfred Pennyworth, pushing Payne out of a window to his death to prevent him from telling the people who hired him that she and Bruce are onto them. Selina also has connections with Ivy Pepper and later befriends Barbara Kean, Gordon's ex-fiance. During the gang war between Carmine Falcone and Sal Maroni, Selina is among the street children recruited into Fish Mooney's gang. When a gang war erupts between Oswald Cobblepot and Mooney for the control of Gotham's underworld, Selina declines to pick a side and slips away during the conflict.

Selina later re-emerges working for Cobblepot's gang and tries to protect Bruce from corrupt billionaire Theo Galavan (James Frain) and his niece, Silver St. Cloud (Natalie Alyn Lind), who competes with Selina for Bruce's affections. Later, Bruce and Selina stage a kidnapping to find out what Silver knows about the Wayne murders. She teams up with Gordon and Cobblepot to save Bruce when he is kidnapped by the Sacred Order of Saint Dumas. She allows Bruce to live on the streets with her for a while and tries to teach him how to fight. When Bruce decides to go back home, Selina angrily spurns his friendship. Selina later volunteers to infiltrate Arkham Asylum to find Hugo Strange's (B.D. Wong) experiments. She also meets Bridgit Pike (Michelle Veintimilla), the alter ego of the vigilante Firefly, and becomes her ally in fighting human traffickers. In the season finale, Selina helps Bruce and Lucius Fox (Chris Chalk) infiltrate Arkham and save Gordon from Edward Nygma (Cory Michael Smith).

When Strange uses experimental technology to revive Fish Mooney, Selina once again goes to work for her. When one of Mooney's minions catches Ivy stealing from her, Selina tries to save her, but is helpless to stop Mooney's thugs from pushing Ivy into a vat of toxic waste.

Later on, Selina encounters Subject 514A (Mazouz), a clone of Bruce created by Strange. After 514A saves Selina during a robbery gone wrong, she sees his scars and realizes he isn't Bruce. 514A explains the situation, and Selina tells him he is more normal than Bruce. With that, 514A kisses Selina and the two part ways. Later, while Selina is stealing wallets at the Cobblepot's party, she encounters Ivy (Maggie Geha), who reveals that Marv (Victor Pagan), one of Mooney's minions, aged her and gave her the power to make plants do her bidding.