Slavery in Libya has a long history and a lasting impact on the Libyan culture. It is closely connected with the wider context of slavery in North Africa and trans-Saharan slave trade.

Since ancient history, the territory of modern Libya was a transit area for the slave trade from Sub-Saharan Africa across the Sahara desert to the Mediterranean Sea. The Trans-Saharan slave trade was known from antiquity and continued until the 20th century. Slavery in Ottoman Libya was nominally prohibited in the 19th century, but the abolition laws were not enforced.

During the Italian colonial period (1912–1951) the slavery and slave trade was finally suppressed in practice. Abolition was, however, a gradual and slow process, and the institution of slavery continued long into the colonial period, particularly in the interior desert areas, where the Italian control was weak. The Trans-Saharan slave trade in the interior of Libya was still in operation as late as the 1930s.

In the 21st century, after the killing of Muammar Gaddafi, the Libyan slave trade of Africans across the Sahara resumed, with open-air slave markets reported in a number of cities in Libya, including the capital city, Tripoli.

As a Roman province, Tripolitania was a major exporter of agricultural products, as well as a centre for the gold and slaves conveyed to the coast by the Garamentes, while Cyrenaica remained an important source of wines, drugs, and horses.

When Amr ibn al-As conquered Tripoli in 643, he forced the Jewish and Christian Berbers to give their wives and children as slaves to the Arab army as part of their jizya. Uqba ibn Nafi would often enslave for himself (and to sell to others) countless Berber girls, "the likes of which no one in the world had ever seen."

Ibn Abd al-Hakam recounts that the Arab General Hassan ibn al-Nu'man would often abduct "young, female Berber slaves of unparalleled beauty, some of which were worth a thousand dinars." Al-Hakam confirms that up to one hundred thousand slaves were captured by Musa and his son and nephew during the conquest of North Africa. In Tangier, Musa enslaved all the Berber inhabitants. Musa sacked a fortress near Kairouan and took with him all the children as slaves. The number of Berbers enslaved "amounted to a number never before heard of in any of the countries subject to the rule of Islam" up to that time. As a result, "most of the African cities were depopulated, [and] the fields remained without cultivation." Even so, Musa "never ceased pushing his conquests until he arrived before Tangiers, the citadel of their [Berbers’] country and the mother of their cities, which he also besieged and took, obliging its inhabitants to embrace Islam."

The historian Pascual de Gayangos observed: “Owing to the system of warfare adopted by the Arabs, it is not improbable that the number of captives here specified fell into Musa’s hands. It appears both from Christian and Arabian authorities that populous towns were not infrequently razed to the ground and their inhabitants, amounting to several thousands, led into captivity.”