The ten principal disciples were the main disciples of Gautama Buddha. Depending on the scripture, the disciples included in this group vary. In many Mahāyāna discourses, these ten disciples are mentioned, but in differing order. The ten disciples can be found as an iconographic group in notable places in the Mogao Caves. They are mentioned in Chinese texts from the fourth century BCE until the twelfth century CE, and are the most honored of the groups of disciples, especially so in China and Central Asia. The ten disciples are mentioned in the Mahāyāna text Vimalakīrti-nideśa, among others. Zhi Dun referred to them as the "Ten Wise Ones" (Chinese: 十哲, romanized: shí zhé), a term normally used for the disciples of Confucius.

Śāriputra (Sanskrit: शारिपुत्र, romanized: Śāriputra; Tibetan: ཤཱ་རིའི་བུ་, Pali: Sāriputta, Khmer: សិរីបុត្រ) (lit. 'the son of Śāri'); born Upatiṣya (Pali: Upatissa); was one of the top disciples of the Buddha. He is considered the first of the Buddha's two chief disciples, together with Maudgalyāyana (Pali: Moggallāna). Śāriputra had a key leadership role in the ministry of the Buddha and is considered in many Buddhist schools to have been important in the development of the Buddhist Abhidharma. He appears in several Mahayana sutras, and in some sutras, is used as a counterpoint to represent the Hinayana school of Buddhism. For example, the Heart Sutra, widely considered to be of utmost centrality to the Mahayana worldview and practice, is framed as an extended discourse delivered to Śāriputra. The sutra consists of radical reinterpretation of early Buddhist thought in the light of emptiness.

Buddhist texts relate that Śāriputra and Maudgalyāyana were childhood friends who became spiritual wanderers in their youth. After having searched for spiritual truth for a while, they came into contact with the teachings of the Buddha and ordained as monks under him, after which the Buddha declared the friends his two chief disciples. Śāriputra was said to have attained enlightenment as an arhat two weeks after ordaining. As chief disciple Śāriputra assumed a leadership role in the Sangha, doing tasks like looking after monks, giving them objects of meditation, and clarifying points of doctrine. He was the first disciple the Buddha allowed to ordain other monks. Śāriputra died shortly before the Buddha in his hometown and was cremated. According to Buddhist texts, his relics were then enshrined at Jetavana Monastery. Archaeological findings from the 1800s suggest his relics may have been redistributed across the Indian subcontinent by subsequent kings.

Śāriputra is regarded as an important and wise disciple of the Buddha, particularly in Theravada Buddhism where he is given a status close to a second Buddha. In Buddhist art, he is often depicted alongside the Buddha, usually to his right. He was known for his strict adherence to the Buddhist monastic rules, as well as for his wisdom and teaching ability, giving him the title "General of the Dharma" (Sanskrit: Dharmasenapati; Pali: Dhammasenāpati). Śāriputra is considered the disciple of the Buddha who was foremost in wisdom. His female counterpart was Khema.

Moggallāna, also known as Mahā Moggallāna or by his birth name Kolita, was one of the Buddha's closest disciples. He is considered the second of the Buddha's two foremost male disciples, together with Śāriputra. Traditional accounts relate that Maudgalyāyana and Śāriputra become spiritual wanderers in their youth. After having searched for spiritual truth for a while, they come into contact with the Buddhist teaching through verses that have become widely known in the Buddhist world. Eventually they meet the Buddha himself and ordain as monks under him. Maudgalyāyana attains enlightenment shortly after that.

Maudgalyayana and Śāriputra have a deep spiritual friendship. They are depicted in Buddhist art as the two disciples that accompany the Buddha, and they have complementing roles as teachers. As a teacher, Maudgalyayana is known for his psychic powers, and he is often depicted using these in his teaching methods. In many early Buddhist canons, Maudgalyāyana is instrumental in re-uniting the monastic community after Devadatta causes a schism. Furthermore, Maudgalyāyana is connected with accounts about the making of the first Buddha image. Maudgalyāyana dies at the age of eighty-four, killed through the efforts of a rival sect. This violent death is described in Buddhist scriptures as a result of Maudgalyāyana's karma of having killed his own parents in a previous life.

Through post-canonical texts, Maudgalyāyana became known for his filial piety through a popular account of him transferring his merits to his mother. This led to a tradition in many Buddhist countries known as the ghost festival, during which people dedicate their merits to their ancestors. Maudgalyāyana has also traditionally been associated with meditation and sometimes Abhidharma texts, as well as the Dharmaguptaka school. In the nineteenth century, relics were found attributed to him, which have been widely venerated.

Mahā Kāśyapa or Mahākāśyapa (Pali: Mahākassapa) is regarded in Buddhism as an enlightened disciple, being foremost in ascetic practice. Mahākāśyapa assumed leadership of the monastic community following the paranirvāṇa (death) of the Buddha, presiding over the First Buddhist Council. He was considered to be the first patriarch in a number of early Buddhist schools and continued to have an important role as patriarch in the Chan and Zen tradition. In Buddhist texts, he assumed many identities, that of a renunciant saint, a lawgiver, an anti-establishment figure, but also a "guarantor of future justice" in the time of Maitreya—he has been described as "both the anchorite and the friend of mankind, even of the outcast".