The Girl Most Likely To...

Miriam Knight is an intelligent, though unattractive young woman who is treated disrespectfully by those around her due to her homely appearance. She has changed colleges five times in three years. In that time, she has taken a lot of different classes, but is still unable to find a boyfriend. At her new college, things go from bad to worse. She is either ignored or humiliated by almost everyone. Miriam finally lands the lead in a play, but her jealous roommate, knowing that Miriam is allergic to roses, places some in a box during Miriam's performance, causing Miriam to sneeze herself into humiliation. She tearfully speeds away from the college campus, but is involved in an automobile accident.

Miriam requires reconstructive surgery on her face. Once the bandages are removed, they reveal a brunette bombshell. From the moment she steps outside the room in the hospital, she makes it her mission to exact vengeance on all those who did her wrong by killing them, one by one.

Miriam uses her new good looks, which make her unrecognizable as the "old" Miriam, and the skills that she acquired in many of her classes to commit the crimes. A police detective, Ralph Varone, who had a brief encounter with the "old" Miriam, solves the crimes committed by the "new" Miriam and discovers her motive. Varone falls in love with Miriam, becoming the only man to love her for her mind. They marry with Miriam in custody, preparing to serve a lengthy jail sentence.