In religion, transcendence is the aspect of existence that is completely independent of the material universe, beyond all known physical laws. This is related to the nature and power of deities as well as other spiritual or supernatural beings and forces. This is contrasted with immanence, where a god is said to be fully present in the physical world and thus accessible to creatures in various ways. In religious experience, transcendence is a state of being that has overcome the limitations of physical existence, and by some definitions, has also become independent of it. This is typically manifested in prayer, rituals, meditation, psychedelics and paranormal visions.

It is affirmed in various religious traditions' concept of the divine, which contrasts with the notion of a god (or, the Absolute) that exists exclusively in the physical order (immanentism), or is indistinguishable from it (pantheism). Transcendence can be attributed in knowledge as well as or instead of its being. Thus, an entity may transcend both the universe and knowledge (is beyond the grasp of the human mind).

Although transcendence is defined as the opposite of immanence, the two are not necessarily mutually exclusive. Some theologians and metaphysicians of various religious traditions affirm that a god is both within and beyond the universe (panentheism); in it, but not of it; simultaneously pervading it and surpassing it.

Jewish theologians, especially since the Middle Ages, have described the transcendence of God in terms of divine simplicity, explaining the traditional characteristics of God as omniscient and omnipotent. Interventions of divine transcendence occur in the form of events outside the realm of natural occurrence such as miracles and the revelation of the Ten Commandments to Moses at Mount Sinai.

In Jewish Kabbalistic cosmology, God is described as the "Ein Sof" (literally, without end) as reference to God's divine simplicity and essential unknowability. The emanation of creation from the Ein Sof is explained through a process of filtering. In the Kabbalistic creation myth referred to as the "breaking of the vessels," filtering was necessary because otherwise this intense, simple essence would have overwhelmed and made impossible the emergence of any distinct creations. Each filter, described as a vessel, captured the emanation of this creative force until it was overwhelmed and broken by the intensity of God's simple essence. Once broken, the vessel's shards, full of absorbed "divine sparks," fell into a vessel below. This process ultimately continued until the "light" of Godliness was sufficiently reduced to allow the world we inhabit to be sustained without breaking. The creation of this world, however, comes with the consequence that Godly transcendence is hidden, or "exiled" (from the immanent world). Only through the revelation of sparks hidden within the shards embedded in our material world can this transcendence be recognized again. In Hasidic thought, divine sparks are revealed through the performance of commandments or "mitzvot," (literally, the obligations and prohibitions described in the Torah). A Kabbalistic explanation for the existence of malevolence in the world is that such terrible things are possible with the divine sparks being hidden. Thus there is some urgency to performing mitzvot in order to liberate the hidden sparks and perform a "tikkun olam" (literally, healing of the world). Until then, the world is presided over by the immanent aspect of God, often referred to as the Shekhinah or divine spirit, and in feminine terms.

The Catholic Church, as do other Christian denominations, holds that God transcends all creation. According to Aquinas, "concerning God, we cannot grasp what he is, but only what he is not, and how other beings stand in relation to him." Anthropomorphic depictions of God are largely metaphorical and reflect the challenge of "human modes of expression" in attempting to describe the infinite. St. Augustine observed "...[I]t is only by the use of such human expressions that Scripture can make its many kinds of readers whom it wants to help to feel, as it were, at home." The "sense of transcendence" and therefore, an awareness of the "sacred", is an important component of the liturgy. Thus, God is recognized as both transcendent and immanent.

Trascendence of God is implicitly affirmed by the First Vatican Council's apostolic constitution Dei Filius:

The holy Catholic Apostolic Roman Church believes and confesses that there is one true and living God, Creator and Lord of heaven and earth, almighty, eternal, immense, incomprehensible, infinite in intelligence, in will, and in all perfection, who, as being one, sole, absolutely simple and immutable spiritual substance, is to be declared as really and essentially distinct from the world, of supreme beatitude in and from Himself, and ineffably exalted above all things which exist, or are conceivable, except Himself.