Twitterrific was a macOS and iOS client for the social networking site Twitter created by The Iconfactory and was the first Twitter desktop client to come to macOS. It lets users view "tweets" or micro-blog posts on the Twitter website in real time as well as publish their own. Twitterrific is closed source software.

The program's main window uses a translucent black theme similar to certain palettes used in Aperture, iPhoto and other Apple Inc. software. Users may choose to view the full public timeline or just the friends feed. Users can also click on links to view the poster's profile or mark a tweet as a favorite.

Twitterrific also provides functionality to upload images and videos for posting on Twitter.

As of version 2.1, Twitterrific supports Growl notifications, enhanced AppleScript capabilities and can be used with other sites or services that use the Twitter API.

Version 3 changed Twitterrific into advertising supported shareware; every hour an ad is refreshed to the top of the list. Users who buy the program receive no ads. Other changes in version 3 mostly added compatibility with Mac OS X 10.5 and incorporated newer Twitter features like direct messaging.

The iOS version of Twitterrific won the 2008 Apple Design Award for Best iPhone Social Networking Application.

On April 1, 2010, The Iconfactory released Twitterrific for iPad (Version 1.0), ready for the iPad's US launch on April 3. On June 24, a version of Twitterrific was launched (version 3.0) that was universally compatible with the iPhone, iPod touch and the iPad.

On February 14, 2017, a Kickstarter project was launched by The Iconfactory to try and revive the Twitterrific for Mac application.