U.S. Route 78
U.S. Route 78
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U.S. Route 78

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U.S. Route 78

U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for 843.6 miles (1,357.6 km) from Swifton, Arkansas, to Charleston, South Carolina. From Byhalia, Mississippi to Graysville, Alabama, US 78 runs concurrently with Interstate 22 (I-22). The highway’s western terminus is at I-57/US 67 near Swifton, and its eastern terminus is on Line Street, in Charleston. Prior to November 2023, before the western extension, the highway's former western terminus was at US 64/US 70/US 79 (Second Street) in Memphis, Tennessee.

US 78 begins at interchange with I-57/US 67 at exit 102 where the roadway continues as AR 226 west toward Swifton. The route goes through towns of Cash, Jonesboro, Lake City, Black Oak, Monette, Manila and Blytheville. In Blytheville, the route runs concurrently with Interstate 55 (I-55) and travels south, going through Marion and West Memphis before turning east and crossing on the Memphis & Arkansas Bridge over the Mississippi River to enter Memphis, Tennessee.

US 78 enters Tennessee along I-55 from Arkansas and shortly after diverges from I-55 onto E.H. Crump Boulevard. It is concurrent with US 61, US 64, US 70, US 79 and State Route 1 (SR 1) until Third Street/B.B. King Boulevard. US 61 turns south onto SR 14 south (Third Street) while US 64, US 70, and US 79 turn north onto SR 4 west and SR 14 north (B.B. King Boulevard) at this intersection. This is also where SR 4 becomes concurrent with US 78 for the remainder of its length. About a 14 mile (0.40 km) later, SR 1 turns north onto (Danny Thomas Boulevard). US 78/SR 4 then continues along E.H. Crump Boulevard to meet two interchanges with I-240 (the first interchange of I-240 is concurrent with I-69). Around I-240, the road changes names to Lamar Avenue and then it meets US 51 and SR 3 before continuing southeastwardly to the Mississippi state line.

In Memphis, US 78 is historically known as Pigeon Roost Road, and some aborted sections of the highway in Mississippi also claim that name as well as Lamar Avenue.

US 78 is a freeway for its entire length in Mississippi. The section from its intersection with I-269 in Byhalia, Mississippi to the Alabama state line is concurrent with I-22. The highway runs across the northeastern rural part of the state, connecting several population centers. Mississippi's portion of US 78 is defined in Mississippi Code Annotated § 65-3-3. The old routing of US 78 through the state is signed as MS 178.

US 78 is a major east–west U.S. highway across the central part of Alabama. It is internally designated SR 4 by the Alabama Department of Transportation, though the only section of SR 4 that is signed is along portions mainly west of Jasper. The section from the Mississippi state line to near Graysville is concurrent with I-22; from Graysville south to Birmingham, US 78 takes its original routing. East of Birmingham to the Georgia state line, US 78 has been replaced as a major through-route by I-20. The two routes roughly parallel each other, with junctions at Leeds and Pell City.

West of Jasper, old US 78 is signed as SR 118 to Guin, and the segment from Guin northward to I-22 at Hamilton is signed as US 43/US 278.

US 78 enters Georgia in Haralson County, passing through the downtowns of Tallapoosa and Bremen. It then proceeds through Carroll County and Douglas County. In Douglasville, located in Douglas County, US 78 runs through the downtown, historical part of the city. It is the original thoroughfare for these Georgia counties.

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