WUFO (1080 kHz) is a commercial AM radio station licensed to Amherst, New York, and serving the Buffalo metropolitan area. It is owned by the Visions Multi Media Group headed by Sheila. L. Brown and it broadcasts a hybrid Urban AC and Classic Hip Hop radio format. Its studios are on Broadway Avenue in Buffalo.

WUFO transmits 1,000 watts non-directional. WUFO is a daytimer station because 1080 AM is a clear-channel frequency reserved for Class A stations WTIC Hartford and KRLD Dallas, so WUFO must sign off at sunset to avoid interference. The transmitter is on Genesee Street in Cheektowaga. Programming is heard around the clock on 35-watt FM translator W243DX at 96.5 MHz. It uses the FM translator frequency in its moniker, "Power 96.5."

The roots of today's WUFO can actually be traced back to 1925, with the founding of WPDQ in Kenmore, New York, a Buffalo suburb. WPDQ was owned by Hiram Turner and Nelson P. Baker (not related to venerable priest Nelson H. Baker) and operated for one day, December 30, 1925, before the Federal Radio Commission suspended its license. By the time the station returned to the air in 1927, it had taken the call sign WKEN. General Order 40 proposed that WKEN share airtime with WKBW, which was moving to the frequency WKEN was using at the time: 1470 kilocycles. WKEN objected and proposed to move down the dial to 1040 and operate as a daytime-only station, then a novel concept. In 1930, WKEN became WMAK, taking on the intellectual property of a station that was displaced when The Buffalo News purchased its frequency. (The other station became WBEN.)

The second incarnation of WMAK ceased operations in 1932, amid the Great Depression and antitrust pressures on the Buffalo Broadcasting Company that owned WGR, WMAK and WKEN at the time. The FRC ordered the station off the air, ostensibly due to "an unsatisfactory showing of public interest."

The Kenmore allocation remained silent for the next 14 years. In the interim, the North American Regional Broadcasting Agreement (NARBA), implemented in 1941, pushed all stations broadcasting on 1040 up the dial to 1080. In 1946, Thaddeus Podbielniak and Edwin R. Sanders (d/b/a Western New York Broadcasting Company) applied to the FCC to construct a 1,000-watt AM radio station on the 1080 allocation in Kenmore. A construction permit was granted in April 1947. The original call sign for the construction permit was WNYB, but when the station signed on in January 1948, it had the new calls WXRA. The city of license was changed from Kenmore to Buffalo in 1952, although its studios and facilities remained in Kenmore. For the first decade or so of its existence, WXRA was a little-noticed full-service radio station offering a wide variety of music and local news.

George "Hound Dog" Lorenz, who later became a Buffalo radio legend on WKBW and started up WBLK 93.7 FM in 1964, had a show on WXRA during its early years, but was eventually fired for playing too much "race music" (the term used for Rhythm and Blues music in those days). After WKBW adopted a Top 40 format in the late 1950s and took away Lorenz' privilege of playing what he wanted, he returned to 1080 AM and attempted to purchase the station, but was outbid by noted radio station owner Gordon McLendon.

In 1957, Podbielniak and Sanders sold WXRA to John Kluge, who went on to found Metromedia, which eventually owned radio and TV stations in New York City, Washington, D.C. and other cities. Kluge changed the station's call letters to WINE and debuted a Top 40 format on 1080 on October 15, 1957. WINE's mascot was a caricature of an inebriated Frenchman, and the station's slogan was "It goes to your head!" WINE's city of license was changed from Buffalo to Amherst in 1959, although by then the station's studio and transmitter were located on LaSalle Avenue, in Buffalo.

Acclaimed broadcaster Gordon McLendon purchased WINE in 1960. In April, McLendon changed the call sign to WYSL (for "Whistle") and dropped the Top 40 format in favor of Beautiful Music. Toward the end of 1961, however, McLendon moved the WYSL call letters and easy listening format to the 1400 spot on the AM dial (formerly WBNY). He sold the 1080 frequency to Dynamic Broadcasting, which instituted the WUFO call sign and recrafted the station as the first radio broadcaster programmed for Buffalo's African American community.