Von Braun led the team that developed the A-4 rocket, the first ballistic missile. This rocket incorporated liquid-fueled propulsion, inertial guidance, and aerodynamic control, representing a significant advance in rocket technology.

The Redstone rocket, derived from the V-2, was the first large liquid-fueled rocket developed by the United States. It was used for early missile testing and as the launch vehicle for America's first satellite, Explorer 1, and the first American manned spaceflights.

The Jupiter-C, a modified Redstone rocket, was used to launch Explorer 1. This rocket demonstrated the potential of multistage rockets for achieving higher altitudes and velocities.

Von Braun's most significant engineering achievement was the Saturn V rocket, the most powerful rocket ever built. The Saturn V utilized multiple stages, powerful liquid-fueled engines (F-1 and J-2), and advanced guidance systems to launch the Apollo missions to the Moon.

Von Braun's work contributed to significant advancements in liquid-fueled rocket propulsion, including the development of high-performance engines, efficient fuel injection systems, and reliable combustion chambers.