Alcoholic beverages appear in the Hebrew Bible, after Noah planted a vineyard and became inebriated. In the New Testament, Jesus miraculously made copious amounts of wine at the wedding at Cana (John 2). Wine is the most common alcoholic beverage mentioned in biblical literature, where it is a source of symbolism, and was an important part of daily life in biblical times. Additionally, the inhabitants of ancient Israel drank beer and wines made from fruits other than grapes, and references to these appear in scripture. However, the alcohol content of ancient alcoholic beverages was significantly lower than modern alcoholic beverages. The low alcohol content was due to the limitations of fermentation and the nonexistence of distillation methods in the ancient world. Rabbinic teachers wrote acceptance criteria on consumability of ancient alcoholic beverages after significant dilution with water, and prohibited undiluted wine.

In the early 19th century the temperance movement began. Evangelical Christians became prominent in this movement, and while previously almost all Christians had a much more relaxed attitude to alcohol, today many evangelical Christians abstain from alcohol. Bible verses would be interpreted in a way that encouraged abstinence, for example 1 Corinthians 10:21, which states, "You cannot drink the cup of the Lord and the cup of demons too..."

Historically, however, the main Christian interpretation of biblical literature displays an ambivalence toward drinks that can be intoxicating, considering them both a blessing from God that brings joy and merriment and potentially dangerous beverages that can be sinfully abused. The relationships between Judaism and alcohol and Christianity and alcohol have generally maintained this same tension, though some modern Christian sects, particularly American Protestant groups around the time of Prohibition, have rejected alcohol as evil. The original versions of the books of the Bible use several different words for alcoholic beverages: at least 10 in Hebrew, and five in Greek. Drunkenness is discouraged and occasionally portrayed, and some biblical persons abstained from alcohol. Wine is used symbolically, in both positive and negative terms. Its consumption is prescribed for religious rites or medicinal uses in some places.

Biblical literature uses several words in its original languages to refer to different types of alcoholic beverages. Some of these words have overlapping meaning, particularly the words in the Hebrew language compared to the words in Koine Greek, the language of both the Septuagint and the New Testament. While some deuterocanonical books may have been originally written in Hebrew or the Aramaic language, some were written in Greek. Hence, the meanings of the words used for alcoholic beverages in each of these languages has bearing on alcohol in the Bible.

The Hebrew Bible was largely written in Biblical Hebrew, with portions in Biblical Aramaic, and has an important Ancient Greek translation called the Septuagint. The modern Hebrew Bible, which generally follows the Masoretic Text, uses several words to represent alcoholic beverages:

The New Testament (Koine Greek) and Septuagint Greek words:

Yayin and oinos (which in the Septuagint also often translates most of the Hebrew words for alcoholic beverages listed above) are commonly translated "wine", but the two are also rarely, and perhaps figuratively or anticipatorily, used to refer to freshly pressed non-alcoholic juice. For this reason, prohibitionist and some abstentionist Christians object to taking the default meaning to be fermented beverages,^{[citation needed]} but others argue that the words can also refer to alcoholic beverages.

After the conquest of Palestine by Alexander the Great, the Hellenistic custom of diluting wine had taken hold such that the author of 2 Maccabees speaks of diluted wine as "a more pleasant drink" and of both undiluted wine and unmixed water as "harmful" or "distasteful."