Amtrak Midwest is a brand name applied by Amtrak to its state-supported routes in the Midwest states of Illinois, Michigan, Wisconsin, Minnesota, and Missouri. As of May 2024^[update], Amtrak Midwest consists of eleven named trains:

The routes generally form a hub-and-spoke network around Chicago Union Station, with all trains terminating there except for one Missouri River Runner round trip.

Other routes in development include the Quad Cities and Northern Lights Express.

As of May 2023^[update], Amtrak Midwest consists of eleven named trains operating in ten service patterns. The Illinois Zephyr and Carl Sandburg share identical routes, as do the Illini and Saluki. The Lincoln Service and Missouri River Runner operate separately except for one daily round trip (trains 318 and 319) in which they are combined. There are 22 Amtrak Midwest round trips each weekday, with the Hiawatha running slightly different frequencies on Fridays, Saturdays, and Sundays.

Indiana is not part of Amtrak Midwest as the state does not sponsor any Amtrak routes, although two Wolverine trips stop at Hammond–Whiting station. Indiana discontinued its only state-supported train, the Hoosier State, in 2019.

State-supported service in the Midwest is supplemented by a number of long-distance Amtrak routes, such as the Empire Builder, California Zephyr and City of New Orleans. These are federally-funded, have separate equipment, and do not fall under the Amtrak Midwest brand.

Amtrak Midwest routes generally share a pool of rolling stock, though certain equipment is exclusive to certain routes. In 2017, 33 Siemens Charger locomotives were delivered for Amtrak Midwest. Siemens Venture coaches debuted in 2022, and will continue to be deployed in the coming years. Both the Chargers and the Ventures are owned by the Illinois Department of Transportation.

The Amtrak Midwest logo and brand were unveiled in 2017 alongside the debut of Siemens Charger locomotives on the Hiawatha.