Andrew DeLuca, M.D., is a fictional character from the medical drama television series Grey's Anatomy, which airs on ABC in the United States, and is portrayed by Giacomo Gianniotti. Gianniotti was cast in April 2015, and his character was promoted to series regular status in January 2016. In 2018, Gianniotti also appeared as a guest in the Grey's Anatomy spin-off series Station 19.

Andrew was introduced at the end of Season 11 as a new surgical intern at Grey Sloan Memorial Hospital and eventually advanced to the position of resident in Season 13. Throughout his time on the show, Andrew formed personal connections with many of the attending surgeons, a rare development among interns and residents. His storyline often focused on his struggles with the pressures of a competitive profession, fitting in with his peers, and navigating personal relationships with his colleagues.

Gianniotti exited the series in season 17. For his performance, Gianniotti received nominations for two Golden Maple Awards in 2016.

On April 15, 2015, it was announced that Giacomo Gianniotti had been cast in an undisclosed role for the final two episodes of Grey's Anatomy's eleventh season, with the possibility of recurring in Season 12. He was promoted to the main cast on January 8, 2016, midway through the twelfth season.

The announcement of Gianniotti's casting and the introduction of his character, Andrew DeLuca, initially received backlash from some fans who felt that DeLuca was intended to replace Derek Shepherd (Patrick Dempsey), a beloved character recently written off the show following Dempsey's departure. However, Gianniotti clarified that this was not the case, stating, "I'm just a new character on the show. I'm not filling any void." He reassured fans that "Andrew won't have any [romantic] intentions with Meredith [Grey] so fans don't have to worry about any threat."

In the early days of portraying DeLuca, Gianniotti struggled with the technical aspects of performing surgeries on screen. He recalled, "My first surgery went terribly because I didn't know the protocol for so many things, and the other actors were laughing at me. I was just getting everything wrong. Like, once you're in the OR, your hands have to be by your chest, otherwise you're no longer sterile — I just didn't know that, or how to hold my instruments." Despite the initial challenges, the lack of strict direction gave Gianniotti the freedom to "fill in the blanks" and develop the character on his own. He described Andrew as "a very honest, genuine, passionate guy" who is "very driven." Gianniotti also noted that Andrew was more of an introvert who, as an adult, was "rediscovering who he is as a man [and] how to date women."

When Andrew DeLuca was young, he and his mother moved to Wisconsin from Italy while his sister, Carina (Stefania Spampinato), stayed behind with their father, Vincenzo DeLuca (Lorenzo Caccialanza). Vincenzo was a renowned but corrupt and mentally unstable surgeon in Italy. After operating in a manic state and causing the deaths of four patients, Vincenzo used his connections and wealth to avoid prosecution, prompting Andrew's mother to leave with him. At some point, Andrew's mother returned to Italy to visit Carina, where she suffered a stroke and died.

There is an inconsistency in the storyline regarding Andrew's family. When Andrew is assaulted by Alex Karev, Maggie Pierce mentions that she will call his parents because they know her. However, later seasons reveal that Andrew's mother had already died and he hadn't seen his father, who was still in Italy, for years.