The Artuqid dynasty (alternatively Artukid, Ortoqid, or Ortokid; Old Anatolian Turkish: أرتقي بيليك, Turkish: Artuklu Beyliği, Artuklular, pl. Artukoğulları) was established in 1102 as a Turkish principality of the Seljuk Empire. It formed a Turkoman dynasty rooted in the Oghuz Döğer tribe, and followed the Sunni Muslim faith. It ruled in Northern Syria and Upper Mesopotamia in the eleventh through thirteenth centuries. The Artuqid dynasty took its name from its founder, Artuk Bey, who was a member of Döger branch of the Oghuz Turks and ruled one of the Turkmen principalities of the Seljuk Empire. Artuk's sons and descendants ruled the three branches in the region: Sökmen's descendants ruled the region around Hasankeyf between 1102 and 1231; Ilghazi's branch ruled from Mardin and Mayyafariqin between 1106 and 1186 (until 1409 as vassals) and Aleppo from 1117–1128; and the Harput line starting in 1112 under the Sökmen branch, and was independent between 1185 and 1233.

The dynasty was founded by Artuk, son of Eksük, a general originally under Malik-Shah I and then under the Seljuk emir of Damascus, Tutush I. Tutush appointed Artuk governor of Jerusalem in 1086. Artuk died in 1091, and was succeeded by his sons Sökmen and Ilghazi who were expelled from Jerusalem by the Fatimid vizier al-Afdal Shahanshah in 1098; the Fatimids lost the city to the Crusaders the following year after the siege of Jerusalem of 1099.

Sökmen and Ilghazi established themselves in Diyarbakır, Mardin, and Hasankeyf in al-Jazira where they came into conflict with the Seljuk sultanate. Sökmen, bey of Mardin, defeated the Crusaders at the Battle of Harran in 1104. Ilghazi succeeded Sökmen in Mardin and imposed his control over Aleppo at the request of the qadi Ibn al-Khashshab in 1118. The next year, Ilghazi defeated the Crusader state Principality of Antioch at the Battle of Ager Sanguinis of 1119.

After pillaging the County of Edessa, Ilghazi made peace with the Crusaders. In 1121, he went north towards Armenia with his son-in-law Mazyad Dubais II ibn Sadaqah and Sultan Malik of Ganja. Ilghazi invaded Georgia and was defeated by David IV of Georgia at the Battle of Didgori of 1121. Ilghazi died in 1122, and although his nephew Belek Ghazi nominally controlled Aleppo, the city was really controlled by ibn al-Khashshab. Ibn al-Kashshab was murdered by Assassins in 1125, and Aleppo fell under the control of Zengi, atabeg of Mosul, in 1128. After the death of Belek Ghazi, the Artuqids were split between Harput, Hasankeyf and Mardin. Sokman's son Rukn al-Dawla Dāʾūd, bey of Hasankeyf, died in 1144, and was succeeded by his son Kara Aslan. Kara Aslan allied with Joscelin II of Edessa against the Zengids, and while Joscelin was away in 1144, Zengi recaptured Edessa, the first of the Crusader states to fall (see Siege of Edessa). The Artuqids became vassals of the Zengids during the reign of Nur al-Din Zengi (r. 1146–1174).

Kara Aslan's son Nūr al-Dīn Muḥammad allied with the Ayyubid sultan Saladin against Kilij Arslan II, Seljuk sultan of Rûm, whose daughter had married Nur ad-Din Muhammad. In the peace settlement with Kilij Arslan II, Saladin gained control of the Artuqid territory, even though the Artuqids were still technically vassals of Mosul, which Saladin did not control. The Seljuk Empire completely disintegrated soon after that in 1194.

The Artuqid dynasty remained in nominal command of al-Jazira, but their power declined under Ayyubid rule. The Hasankeyf branch conquered Diyarbakır in 1198 and its center was moved here, but was demolished by the Ayyubids in 1231 when it attempted to form an alliance with the Seljuks. The Harput branch was destroyed by the Sultanate of Rum due to following a slippery policy between the Ayyubids and Seljuks. The Mardin branch survived for longer, but as a vassal of the Ayyubids, Sultanate of Rûm, Il-Khanate, Timurids and the Qara Qoyunlu. Qara Arslan (r.1260–1292), ruler of Mardin, submitted to the Mongol Hulegu. Qara Qoyunlu ruler Qara Mahammad invaded Mardin in 1384 and received the submission of its Artuqid ruler Majd al-Din Isa Al-Zahir (1376-1407). From this point onwards, the Artuqids operated as a vassal state of the Qara Qoyunlu. The Qara Qoyunlu captured Mardin and finally put an end to Artuqid rule in 1409.

Despite their constant preoccupation with war, members of the Artuqid dynasty left many architectural monuments. Artuqid rulers commissioned many public buildings, such as mosques, bazaars, bridges, hospitals and baths for the benefit of their subjects. They left an important cultural heritage by contributing to literature and the art of metalworking. The door and door handles of the great Mosque of Cizre are unique examples of Artuqid metal working craftsmanship, which can be seen in the Turkish and Islamic Arts Museum in Istanbul, Turkey.

They made the most significant additions to Diyarbakır City Walls. Urfa Gate was rebuilt by Muhammad, son of Kara Arslan. In the same area of the western wall, south of Urfa Gate, two imposing towers, Ulu Beden and Yedi Kardeş were commissioned in 1208 by the Artuqid ruler Nāṣir al-Dīn Maḥmūd who designed the Yedi Kardeş tower himself and apposed the Artuqid double-headed eagle on its walls.