The Belgian Comic Strip Center (French: Centre belge de la bande dessinée; Dutch: Belgisch Stripcentrum) is a museum in central Brussels, Belgium, dedicated to Belgian comics. It is located at 20, rue des Sables/Zandstraat, in an Art Nouveau building designed by Victor Horta, and can be accessed from Brussels-Congress railway station and Brussels-Central railway station.

The building that would later house the Belgian Comic Strip Center was inaugurated in 1906 as the Magasins Waucquez [fr], designed in Art Nouveau style by the architect Victor Horta to serve as a large fabric store for the textile baron Charles Waucquez. This period, in the late 19th to early 20th centuries, coincided with the beginnings of modern comic strips.

After Waucquez's death in 1920, the building began to languish away, and in 1970, the firm closed its doors. The architect Jean Delhaye [fr], a former student and aide of Horta, brought the endangered Waucquez building to the attention of the state, and by 16 October 1975, because of its connection to Horta, it was designated a historic monument. Still, the building was in bad shape and victim to a lot of vandalism.

In 1980, the architect Jean Breydel and the comics artists François Schuiten, Bob de Moor, Alain Baran, Guy Dessicy, and Hergé, planned to restore the building and give it a new destination as a museum dedicated to the history of Belgian comics. Originally, the museum would be a homage to Hergé, but he suggested honouring the entire Belgian comics industry. In 1983, the Minister of Public Works, Louis Olivier, purchased the building from the owners' heirs on behalf of the Belgian government's Régie des Bâtiments (English: Buildings Agency), making it national property. In 1984, the Belgian Comic Strip Center (French: Centre belge de la bande dessinée, Dutch: Belgisch Centrum voor het Beeldverhaal) was founded as a non-profit organisation, with Bob De Moor as its first chairman. A fund was established bringing together several Flemish and Walloon comics artists.

In 1986, the launch of the project was celebrated, despite the building still being in ruins. Intensive lobbying, including a luncheon at the Royal Palace and a soirée with the Belgian comic strip community, helped secure the project. Restoration work began in 1987, coordinated by the architect Christian Lelubre and executed by Pierre Van Assche, who designed the plans. The restoration included updating the building to modern standards, while respecting Horta's original work. The mosaics were flown over from Italy and constructed by Italian mosaic workers due to the profession being largely obsolete in Belgium.

On 6 October 1989, the museum was officially inaugurated in the presence of King Baudouin and Queen Fabiola. Over the following decades, the Belgian Comic Strip Center became a major museum with international appeal, welcoming around 200,000 visitors annually, while government subsidies accounted for less than 10% of its working budget. By 2015, the museum began redecorating its permanent exhibition, continuing its mission as a promotional tool, exhibition venue, research centre, and cultural ambassador for Belgian comics and Art Nouveau architecture.

Since 2009, directly across the street from the Belgian Comic Strip Center, another comics-themed museum opened, the Marc Sleen Museum, dedicated to the work of Belgian comics artist Marc Sleen. On 30 January 2023, it was announced that the museum would close in the autumn, with part of its collection being integrated into the Belgian Comic Strip Center.

The building was designed in 1905 by Victor Horta in Art Nouveau style and completed in 1906 as a textile department store. It is the only surviving example of a series of Horta's department stores, notable for its use of iron and glass, a central atrium, and a monumental staircase. The building was protected as a monument in 1975 and renovated in 1988–89 to restore its architectural details while adapting it for public use.