Camden Station, now also referred to as Camden Street Station, Camden Yards, and formally as the Transportation Center at Camden Yards, is a train station at the intersection of South Howard and West Camden Streets in Baltimore, Maryland, adjacent to Oriole Park at Camden Yards, behind the B&O Warehouse. It is served by MARC commuter rail service and local Light Rail trains.

Camden Street Station was originally built beginning in 1856, continuing until 1865, by the Baltimore and Ohio Railroad as its main passenger terminal and early offices/ headquarters (until 1881) in Baltimore and is one of the longest continuously operated terminals in the United States. Its upstairs offices were the workplace of famous Civil War era B&O President John Work Garrett (1820–1884). The station and its environs were also the site of several infamous civil strife actions of the 19th century with the Baltimore riot of 1861, on April 18–19, also known as the Pratt Street Riots and later labor strife in the Great Railroad Strike of 1877.

In 1852, the board of directors of the Baltimore and Ohio Railroad (B&O) approved the purchase of five blocks of land fronting on Camden Street at a cost of $600,000 for the construction of a new passenger and freight station to serve the city of Baltimore from a larger, more centrally located site than the B&O's 1830s–1850s depot, Mount Clare Station. Architectural renderings for Camden Station were submitted by the firm of Niernsee and Neilson in 1855. Construction began in phases in 1856 under the supervision of Baltimore architect Joseph F. Kemp, who also partly designed the final version, a three-story brick structure with three towers in the Italianate architectural style. The center section was substantially completed by 1857; thereafter, the station was used by the B&O's passenger trains until the 1980s, one of the longest continuously operated railroad terminals in the U.S. Construction was completed in 1867 with the addition of two wings and the towers following the end of the Civil War. The station's center tower was originally 185 feet (56 m) high.

In February, 1861, Abraham Lincoln transferred from the President Street station, to the Camden Station on his way to Washington, D.C. to be inaugurated as President of the United States. News of the Battle of Fort Sumter, beginning the Civil War, first reached Baltimore on April 12, 1861, at the B&O's Camden Station telegraph office. The following week, Union troops of the 6th Massachusetts Militia travelling south on the B&O barricaded themselves at Camden Station when they were attacked by Confederate sympathizers in the Baltimore riot of 1861.

During the four-year conflict, the B&O's line between Baltimore and Washington, D.C. was the sole rail link between the Federal capitol and the North, resulting in a vital role for Camden Station as B&O's Baltimore terminal. Trainloads of wounded soldiers and Confederate POWs came through the station following the Battle of Antietam, 75 miles (121 km) west of Baltimore on September 17, 1862. President Lincoln changed trains at Camden Station on November 18, 1863 en route to Gettysburg, Pennsylvania to deliver the Gettysburg Address. Lincoln also used Camden Station on April 18, 1864 when he made an overnight visit to Baltimore for a speaking engagement. A year later, at 10 a.m. on April 21, 1865, the assassinated president's nine-car funeral train arrived at Camden Station, the first stop on its slow journey from Washington to Springfield, Illinois, via the B&O and the Northern Central Railway's Baltimore-Harrisburg, Pennsylvania, line.

In July 1877, the station was the site of riots and clashes between the Maryland National Guard and strikers during the Baltimore railroad strike, which occurred as part of the Great Railroad Strike of the same year. Some in the crowd attempted to set fire to the station, and nearby buildings associated with the Baltimore & Ohio Railroad, but were largely unsuccessful.

Beginning in 1897, Camden Station also had lower-level platforms for B&O's New York–Washington passenger trains, which used the Howard Street tunnel to reach Mount Royal Station. The first mainline electrification of a steam railroad in the U.S. occurred at Camden Station on June 27, 1895, when an electric locomotive pulled a Royal Blue train through the Howard Street tunnel.

In 1912, the B&O remodeled the central waiting room, enlarging it and adding oak panelling with marble wainscoting for the Democratic National Convention, held in Baltimore that year. The Annapolis & Baltimore Short Line Railroad also used Camden Station for its trains to Annapolis, Maryland, beginning in 1887. Except for an interval between 1921 and 1935, when the successor Washington, Baltimore and Annapolis Electric Railway (WB&A) used a separate station at Howard and Lombard Streets, frequent electric interurban trains to Maryland's capitol served Camden station until February 5, 1950, when WB&A successor Baltimore and Annapolis Railroad replaced rail passenger service with buses.