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His maternal grandparents were Elisabeth (née Langley) Sloane and Sir Hans Sloane, 1st Baronet.[2] Following the 1780 suicide of his cousin, AmbassadorHans Stanley (son of his maternal aunt Sarah Sloane Stanley and George Stanley of Paultons), he inherited Stanley's half of the Sloane estate.[2][3]
In 1777 he leased 100 acres (0.40 km2) of the family estate in Chelsea to architect Henry Holland for building development. Holland built Sloane Square, Sloane Street, Cadogan Place and Hans Place.[8] Lord Cadogan also served as Sloane Trustee of the British Museum from 1779 until his death in 1807.[9]
On 30 May 1747, Cadogan married Frances Bromley, a daughter of Henry Bromley, 1st Baron Montfort and the former Frances Wyndham (only daughter of Thomas Wyndham of Trent). Together, they had six sons:[6]
Henry William Cadogan (1761–1774), who died young.[10]
Cadogan's first wife died in 1768, and on 10 May 1777, he married Mary Churchill, a daughter of Col. Charles Churchill and Lady Mary Walpole (a daughter of former Prime MinisterRobert Walpole). Together, Mary and Charles were the parents of three sons and three daughters before they divorced in 1796:[6][10]
Lady Louisa Cadogan (1787–1843), who married the Rev. William Marsh in 1840.[10]
Lt. Colonel Edward Cadogan (1789–1851), who married Ellen Donovan, daughter of Laurence Donovan in 1823, and then, secondly, Jeanne Marie-Zoé Dipierrin in 1849 at Tarbes, France. He died at Château Ayzac.[12][13]