Croatian wine (vino, pl. vina) has a history dating back to the Ancient Greek settlers, and their wine production on the southern Dalmatian islands of Vis, Hvar and Korčula some 2,500 years ago. Like other old world wine producers, many traditional grape varieties still survive in Croatia, perfectly suited to their local wine hills. Modern wine-production methods have taken over in the larger wineries and EU-style wine regulations have been adopted, guaranteeing the quality of the wine.

There are currently over 300 geographically defined wine regions and a strict classification system to ensure quality and origin. The majority of Croatian wine is white, with most of the remainder being red and only a small percentage being rosé wines. In 2014, Croatia ranked 32nd in wine production by country with an estimated 45,272 tonnes.

Wine is a popular drink in Croatia, and locals traditionally like to drink wine with their meals. Quite often, the wine is diluted with either still or sparkling water—producing drinks known as gemišt (a combination of white wine and carbonated water) and bevanda (a combination of red wine and still water).

Like the rest of Central Europe and Southern Europe, viticulture in the present-day Croatia existed hundreds of years before the rise of the Roman Empire. Recent research has shown that the Illyrians living in Dalmatia during the Bronze Age and Iron Age may already have grown grapevines. However, the true beginning of grape cultivation and wine production in Croatia is related to the Ancient Greeks settlers, who arrived on the Croatian coast in the 5th century BC. The Greek writer Athenaeus wrote 18 centuries ago about the high quality wine produced on the Dalmatian islands of Vis, Hvar and Korčula. Coins from the period have motifs related to grape cultivation and wine, demonstrating the importance of wine in the economics of the ancient Greek colonies.

Under the Roman Empire, wine production grew, becoming more organized. Wine was exported to other parts of the empire. Artifacts from this time include stone presses for squeezing grapes and amphoras from sunken Roman galleys. Decorations on numerous religious and household items bear witness to the wine-making culture.

As the Croatians arrived and settled the area, they learned from their predecessors, and wine production continued to expand. During the Middle Ages, there was a royal court official called the "royal wine procurer", whose responsibilities included the production and procurement of wine. Free towns adopted legal standards on winegrowing and protected it accordingly. For example, a statute of the town and island of Korčula in 1214 contains strict rules protecting the vineyards.

In the 15th century, the Ottoman Turks arrived in South Eastern Europe, and imposed strict anti-alcohol laws as part of the new Islamic law. Fortunately, the Ottoman Empire was tolerant of Christianity. Catholic church traditions involving wine may have “saved” local wine production from complete extinction—as priests and monks were permitted to continue making wine for church services.

In the 18th century, much of present-day Croatia came under control of the Habsburg Empire, where wine production flourished through the 19th and 20th centuries. The history of wine changed dramatically in 1874, when phylloxera, a hazardous grapevine pest, started to appear in Europe. Wine production dropped, first in France and Germany, as growers struggled with the blight. For a time, Croatian vineyards remained unaffected, and wine exports greatly increased to fill the demand. Some French companies even planted vines in Croatia with a view to expanding operations in the safe area. However, by the turn of the 20th century, Croatian vines had also succumbed to phylloxera, leading to the destruction of the vineyards and the collapse of the local economy in many areas. Large numbers of winegrowing families moved to the new world, contributing to the growth of wine production there.