The Dutch Cape Colony (Dutch: Nederlandse Kaapkolonie), officially known as the Cape of Good Hope Waystation (Dutch: Tussenstation Kaap de Goede Hoop), was a colony of the Dutch East India Company (VOC) and Batavian Republic in Southern Africa. Centered on the Cape of Good Hope, from where it derived its name, it was founded in 1652 by a VOC expedition under Jan van Riebeeck to serve as a re-supply and layover port for VOC vessels trading with Asia. The Cape was under VOC rule from 1652 to 1795 and Batavian rule from 1803 to 1806. Much to the dismay of the VOC's shareholders, who focused primarily on making profits from the Asian trade, the Cape Colony rapidly expanded into a settler colony in the years after its founding.

As the only permanent settlement of the VOC which served as a trading post, it proved an ideal retirement place for employees of the company. After several years of service in the company, an employee could lease a piece of land in the Cape Colony as a Free Burgher, on which he had to cultivate crops that he had to sell to the VOC for a fixed price. As these farms were labour-intensive, Free Burghers imported slaves from Madagascar, Mozambique and Asia (mostly the Dutch East Indies and Dutch Ceylon), which rapidly increased the number of inhabitants. After King Louis XIV of France issued the Edict of Fontainebleau in October 1685 (revoking the Edict of Nantes of 1598), thereby ending protection of the right of Huguenots in France to practise Protestant worship without persecution from the state, the Cape Colony attracted some Huguenot settlers, who eventually mixed with the general Dutch population.

Due to the authoritarian rule of the company (telling farmers what to grow for what price, controlling immigration, and monopolising trade), some farmers tried to escape the rule of the company by moving further inland. The company, in an effort to control these migrants, established a magistracy at Swellendam in 1745 and another at Graaff Reinet in 1786, and declared the Gamtoos River as the eastern frontier of the Cape, only to see the Trekboers cross it soon afterwards. In order to keep out Cape native pastoralists, organised increasingly under the rising Xhosa people, the VOC agreed in 1780 to make the Great Fish River the boundary of the Cape.

In 1795, after they launched an invasion of the Cape Colony in present-day Cape Town, the British occupied the Cape. Under the terms of the Peace of Amiens of 1802, Britain ceded the Cape back to the Batavian Republic on 1 March 1803, but as the Batavians had nationalized the VOC in 1796, the Cape Colony now became a colony under the direct rule of The Hague. Batavian control did not last long, however, as the outbreak of the Napoleonic Wars on 18 May 1803 invalidated the Peace of Amiens. In January 1806, the British occupied the colony for a second time after their victory at the Battle of Blaauwberg at present-day Bloubergstrand. The Anglo-Dutch Treaty of 1814 confirmed the transfer of sovereignty to Britain.

Traders of the United East India Company (VOC), under the command of Jan van Riebeeck, were the first people to establish a European colony in South Africa. The Cape settlement was built by them in 1652 as a re-supply point and way-station for United East India Company vessels on their way back and forth between the Netherlands and Batavia (Jakarta) in the Dutch East Indies. The support station gradually became a settler community, the forebears of the Boers, and the Cape Dutch who became Afrikaners.

At the time of first European settlement in the Cape, the southwest of Africa was inhabited by Khoikhoi pastoralists and hunters. Disgruntled by the disruption of their seasonal visit to the area for which purpose they grazed their cattle at the foot of Table Mountain only to find European settlers occupying and farming the land, leading to the first Khoi-Dutch War as part of a series of Khoikhoi–Dutch Wars. After the war, the natives ceded the land to the settlers in 1660. During a visit in 1672, the high-ranking Commissioner Arnout van Overbeke made a formal purchase of the Cape territory, although already ceded in 1660, his reason was to "prevent future disputes".

The ability of the European settlers to produce food at the Cape initiated the decline of the nomadic lifestyle of the Khoi and Tuu speaking peoples since food was produced at a fixed location. Thus by 1672, the permanent indigenous residents living at the Cape had grown substantially. The first school to be built in South Africa by the settlers were for the sake of the slaves who had been rescued from a Portuguese slave ship and arrived at the Cape with the Amersfoort in 1658. Later on, the school was also attended by the children of the indigenes and the Free Burghers. The Dutch language was taught at schools as the main medium for commercial purposes, with the result that the indigenous people and even the French settlers found themselves speaking Dutch more than their native languages. The principles of Christianity were also introduced at the school resulting in the baptisms of many slaves and indigenous residents.

Conflicts with the settlers and the effects of smallpox decimated their numbers in 1713 and 1755, until gradually the breakdown of their society led them to be scattered and ethnically cleansed beyond the colonial frontiers: both beyond the Eastward-expanding frontier (to form eventually the future resisting population of the frontier wars), as well as beyond the Northern open frontier war above the Great Escarpment.