EgyptAir Flight 804 was a regularly scheduled international passenger flight from Paris Charles de Gaulle Airport to Cairo International Airport, operated by EgyptAir. On 19 May 2016 at 02:33 Egypt Standard Time (UTC+2), the Airbus A320 crashed into the Mediterranean Sea, killing all 66 occupants on board.

No mayday call was received by air traffic control, although signals that smoke had been detected in one of the aircraft's lavatories and in the avionics bay were automatically transmitted via ACARS shortly before the aircraft disappeared from radar. The last communications from the aircraft prior to its submersion were two transmissions from its emergency locator transmitter that were received by the International Cospas-Sarsat Programme. Debris from the aircraft was found in the Mediterranean Sea approximately 290 km (180 mi) north of Alexandria. Nearly four weeks after the crash, several main sections of wreckage were identified on the seabed, and both flight recorders were recovered in a multinational search and recovery operation. On 29 June, Egyptian officials announced that the flight data recorder data indicated smoke in the aircraft, and that soot plus damage from high temperatures was found on some of the wreckage from the front section of the aircraft.

On 30 October 2024, two reports were released with conflicting conclusions about the cause of the crash. Egypt's Civil Aviation Authority, which headed the investigation, concluded that the crash was the result of an explosion occurring in the galley near the cockpit, which was rapidly engulfed by smoke and fire, exacerbated by oxygen flow being present. The French investigative agency BEA disagreed with this conclusion, instead finding that the fire was most likely a result of a fault in the oxygen mask.

The aircraft involved, manufactured in 2003, was an Airbus A320-232, registered as SU-GCC with serial number 2088. It was equipped with two IAE V2527-A5 engines. The Airbus A320, introduced in 1988, is a twin-engine aircraft that can seat up to 180 passengers in a high-density layout, although it typically seats 150 passengers, and has a range of up to 6,480 kilometres (3,500 nmi). The aircraft involved was delivered new to Egyptair in November 2003, and had logged 48,052 flight hours in 20,773 flight cycles since its manufacture.

The flight was the aircraft's fifth that day, having flown from Asmara International Airport, Eritrea, to Cairo; then from Cairo to Tunis–Carthage International Airport, Tunisia, and back; the aircraft then departed for Paris Charles de Gaulle Airport via Cairo, from Tunis.

Fifty-six passengers from twelve different countries were on board. Three passengers were reported to be children, including two infants. Some of the passengers held multiple citizenship.

The crew of ten consisted of two pilots, five flight attendants, and three security personnel. The captain, 36-year-old Mohamed Shoukair, had 6,640 hours of flying experience, including 2,108 hours on the A320. The first officer, 25-year-old Mohamed Assem, had 2,966 total flying hours, including 2,771 hours on the A320.

The aircraft departed for Cairo International Airport from Charles de Gaulle Airport on 18 May 2016 at 23:09 (all times refer to UTC+2, used in France and Egypt at the time). It disappeared from radar while flying at flight level 370 (about 37,000 ft (11,300 m) in altitude) in clear weather, 280 km (170 mi; 150 nmi) north of the Egyptian coast, and about the same distance from Kastellorizo, over the eastern Mediterranean on 19 May at 02:30. The aircraft crashed into the sea at around 02:33, when the last ACARS message was sent. The flight had lasted 3 hours 25 minutes.