Rose quickly joined abolitionist organizations in New York City and became an active member of the movement. She believed that slavery was a moral abomination and a violation of fundamental human rights.

Rose consistently incorporated anti-slavery themes into her lectures and public speeches. She condemned the institution of slavery and called for its immediate abolition, often facing hostile reactions from pro-slavery audiences.

Rose wholeheartedly supported the Union cause during the Civil War, viewing the conflict as an opportunity to finally end slavery in the United States. She continued to speak out against slavery and in favor of emancipation.

Rose celebrated the Emancipation Proclamation as a major step toward ending slavery, but she also recognized that much work remained to be done to secure full equality for African Americans.

Following the Civil War, Rose advocated for a just and equitable Reconstruction, including the extension of suffrage to African American men. She believed that black men should have the right to vote to protect their newly won freedoms.