Ernestine married William Rose in England. Their marriage was based on mutual respect and a shared commitment to social justice. They remained married for over 30 years until William's death.

Ernestine and William Rose did not have children. Rose dedicated her life to activism and public speaking, which may have influenced their decision not to have children.

The Roses lived in New York City for over three decades. Their home became a gathering place for reformers, intellectuals, and activists. They hosted numerous meetings and discussions on a variety of social and political issues.

Rose developed close friendships with many prominent activists, including Susan B. Anthony, Elizabeth Cady Stanton, Lucretia Mott, and William Lloyd Garrison. These friendships provided support and inspiration for her work.

In the late 1860s, Rose's health began to decline. She suffered from chronic illness, which made it increasingly difficult for her to continue her activism. Eventually, she and William decided to return to Europe.

Ernestine and William Rose returned to England for health reasons and to be closer to family. They continued to follow developments in the United States and remained committed to social justice.

William Rose died in England in 1882. Ernestine Rose mourned his loss deeply and continued to live in England for the remaining years of her life.

Ernestine Rose died in Brighton, England, at the age of 82. She was remembered as a fearless advocate for women's rights, abolition, and freethought. Her legacy continues to inspire activists and reformers today.