Upon arriving in the US, Rose quickly became involved in reform circles, focusing on women's rights, abolitionism, and freethought. She delivered lectures and organized meetings, often facing hostility for her radical views.

Rose played a key role in advocating for the New York Married Women's Property Act, which allowed married women to own and control their own property. She tirelessly lobbied legislators and mobilized public support for the legislation.

Rose actively participated in the first National Women's Rights Convention, where she delivered a powerful speech advocating for equal rights for women in all spheres of life.

Rose became a prominent and sought-after speaker at women's rights conventions across the United States. She debated with opponents, inspired audiences, and helped shape the movement's agenda.

Rose participated in a highly publicized debate in Albany, New York, arguing for women's suffrage before the state legislature. Her eloquence and logical arguments impressed many, though immediate legislative action was not taken.