GNG2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4KFM, 5HE3, 5HE0, 5HE2, 5HE1
Identifiers
Aliases	GNG2, G protein subunit gamma 2
External IDs	OMIM: 606981; MGI: 102705; HomoloGene: 40715; GeneCards: GNG2; OMA:GNG2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.1 Start 51,826,195 bp[1] End 51,979,342 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 A3|14 11.17 cM Start 19,922,627 bp[2] End 20,027,695 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ganglionic eminence left testis right testis bone marrow cell Brodmann area 46 middle temporal gyrus epithelium of colon blood spinal ganglia Top expressed in dentate gyrus of hippocampal formation granule cell ganglionic eminence medial ganglionic eminence dorsomedial hypothalamic nucleus granulocyte paraventricular nucleus of hypothalamus arcuate nucleus subiculum lateral hypothalamus median eminence More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity G-protein beta-subunit binding protein binding GTPase activity Cellular component heterotrimeric G-protein complex plasma membrane extracellular exosome membrane G-protein beta/gamma-subunit complex Biological process cellular response to glucagon stimulus cell population proliferation signal transduction cellular response to catecholamine stimulus platelet activation adenylate cyclase-activating dopamine receptor signaling pathway cellular response to prostaglandin E stimulus protein folding Wnt signaling pathway, calcium modulating pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54331 14702 Ensembl ENSG00000186469 ENSMUSG00000043004 UniProt P59768 P63213 RefSeq (mRNA) NM_001243773 NM_001243774 NM_053064 NM_001038637 NM_001285908 NM_001285909 NM_001285910 NM_001285911 NM_010315 RefSeq (protein) NP_001230702 NP_001230703 NP_444292 NP_001033726 NP_001272837 NP_001272838 NP_001272839 NP_001272840 NP_034445 Location (UCSC) Chr 14: 51.83 – 51.98 Mb Chr 14: 19.92 – 20.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 is a protein that in humans is encoded by the GNG2 gene.^[5][6]

Heterotrimeric G proteins play vital roles in cellular responses to external signals. The specificity of a G protein-receptor interaction is primarily mediated by the gamma subunit.[supplied by OMIM]^[6]

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Nicotine Activity on Dopaminergic Neurons edit]]

Nicotine Activity on Dopaminergic Neurons edit

1. ^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

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• Yu Y, Zhang C, Zhou G, Wu S, Qu X, Wei H, Xing G, Dong C, Zhai Y (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
• Lowry WE, Huang XY (2002). "G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase". J. Biol. Chem. 277 (2): 1488–92. doi:10.1074/jbc.M110390200. PMID 11698416.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cuello F, Schulze RA, Heemeyer F, Meyer HE, Lutz S, Jakobs KH, Niroomand F, Wieland T (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi:10.1074/jbc.M210304200. PMID 12486123.
• Melliti K, Grabner M, Seabrook GR (2003). "The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells". J. Physiol. 546 (Pt 2): 337–47. doi:10.1113/jphysiol.2002.026716. PMC 2342512. PMID 12527722.
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• Niu J, Profirovic J, Pan H, Vaiskunaite R, Voyno-Yasenetskaya T (2003). "G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production". Circ. Res. 93 (9): 848–56. doi:10.1161/01.RES.0000097607.14733.0C. PMID 14512443. S2CID 85928866.
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• Doering CJ, Kisilevsky AE, Feng ZP, Arnot MI, Peloquin J, Hamid J, Barr W, Nirdosh A, Simms B (2004). "A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium channels". J. Biol. Chem. 279 (28): 29709–17. doi:10.1074/jbc.M308693200. PMID 15105422.

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