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GR-55562

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GR-55562

GR-55562 is a selective serotonin 5-HT1B and 5-HT1D receptor antagonist. It is one of several selective serotonin 5-HT1B receptor antagonists used in scientific research.

The drug is a silent antagonist of the serotonin 5-HT1B receptor, unlike the related agent GR-127935. GR-55562 has around 10-fold selectivity for the serotonin 5-HT1B receptor over the serotonin 5-HT1D receptor and has only weak affinity for a number of other serotonin receptors.

It is ineffective in attenuating MDMA-induced prosocial behavior in animals. Conversely, the serotonin 5-HT1A receptor antagonist WAY-100635 can abolish MDMA-induced prosocial behavior.

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