Iodine is a chemical element; it has symbol I and atomic number 53. The heaviest of the stable halogens, it exists at standard conditions as a semi-lustrous, non-metallic solid that melts to form a deep violet liquid at 114 °C (237 °F), and boils to a violet gas at 184 °C (363 °F). The element was discovered by the French chemist Bernard Courtois in 1811 and was named two years later by Joseph Louis Gay-Lussac, after the Ancient Greek Ιώδης, meaning 'violet'.

Iodine occurs in many oxidation states, including iodide (I⁻), iodate (IO⁻
₃), and the various periodate anions. As the heaviest essential mineral nutrient, iodine is required for the synthesis of thyroid hormones. Iodine deficiency affects about two billion people and is the leading preventable cause of intellectual disabilities.

The dominant producers of iodine today are Chile and Japan. Due to its high atomic number and ease of attachment to organic compounds, it has also found favour as a non-toxic radiocontrast material. Because of the specificity of its uptake by the human body, radioactive isotopes of iodine can also be used to treat thyroid cancer. Iodine is also used as a catalyst in the industrial production of acetic acid and some polymers.

It is on the World Health Organization's List of Essential Medicines.

In 1811, iodine was discovered by French chemist Bernard Courtois, who was born to a family of manufacturers of saltpetre (an essential component of gunpowder). At the time of the Napoleonic Wars, saltpetre was in great demand in France. Saltpetre produced from French nitre beds required sodium carbonate, which could be isolated from seaweed collected on the coasts of Normandy and Brittany. To isolate the sodium carbonate, seaweed was burned and the ashes washed with water. While investigating the cause of corrosion to the copper vessels used in the process, Courtois added an excess of sulfuric acid to the waste remaining and a cloud of violet vapour arose. He noted that the vapour crystallised on cold surfaces, forming dark crystals. Courtois suspected that this material was a new element but lacked funding to pursue it further.

Courtois gave samples to his friends, Charles Bernard Desormes (1777–1838) and Nicolas Clément (1779–1841), to continue research. He also gave some of the substance to chemist Joseph Louis Gay-Lussac (1778–1850), and to physicist André-Marie Ampère (1775–1836). On 29 November 1813, Desormes and Clément made Courtois' discovery public by describing the substance to a meeting of the Imperial Institut de France. On 6 December 1813, Gay-Lussac found and announced that the new substance was either an element or a compound of oxygen and he found that it is an element. Gay-Lussac suggested the name "iode" (anglicised as "iodine"), from the Ancient Greek Ιώδης (iodēs, "violet"), because of the colour of iodine vapour. Ampère had given some of his sample to British chemist Humphry Davy (1778–1829), who experimented on the substance and noted its similarity to chlorine and also found it as an element. Davy sent a letter dated 10 December to the Royal Society stating that he had identified a new element called iodine. Arguments erupted between Davy and Gay-Lussac over who identified iodine first, but both scientists found that both of them identified iodine first and also knew that Courtois is the first one to isolate the element.

In 1873, the French medical researcher Casimir Davaine (1812–1882) discovered the antiseptic action of iodine. Antonio Grossich (1849–1926), an Istrian-born surgeon, was among the first to use sterilisation of the operative field. In 1908, he introduced tincture of iodine as a way to rapidly sterilise the human skin in the surgical field.

In early periodic tables, iodine was often given the symbol J, for Jod, its name in German; in German texts, J is still frequently used in place of I.