Isaac "Ike" Perlmutter (Hebrew: יצחק "אייק" פרלמוטר; born December 1, 1942)^{[citation needed]} is an Israeli-American billionaire businessman and financier. Through a variety of sometimes unorthodox business deals, he has been an influential investor in a number of corporations, including Revco drug stores, Coleco Entertainment, Remington, and Toy Biz/Marvel Toys. He is the former chairman and CEO of Marvel Entertainment. He has a political relationship with Donald Trump, and acted as an unofficial advisor in his presidential administration, overseeing the Department of Veterans Affairs.

Isaac Perlmutter was born to a Jewish family in Mandatory Palestine in 1942. He served in the Israel Defense Forces during the Six-Day War of 1967.

He emigrated to America, arriving in New York City, and he earned a living standing outside Jewish cemeteries in Brooklyn, leveraging his Hebrew skills to lead funeral services for tips. Later he sold toys and beauty products on the streets of New York City, which eventually evolved into selling surplus stock and end-of-line items at a profit. Although he never attended a university, he taught himself how to read a balance sheet and worked at spotting overlooked value in weak and distressed companies.

With a new partner, Bernard Marden, and leveraging the skills he attained as a wholesaler, he formed a company called Odd Lot Trading, a wholesaler and retailer of closeout items. In May 1984, they sold Odd Lot to Revco Discount Drug Stores in exchange for 12% of Revco stock. He soon challenged Revco management for control of the company but, after initial positive feedback, was rejected. Perlmutter and his partner threatened a hostile takeover but eventually refrained and sold their share back to Revco for $120 million.

Perlmutter had a close relationship with the management of toy manufacturer Coleco Entertainment Corporation as he had been purchasing unsold inventory from them for some time. As is typical in the industry, payment terms were often unusual. With Coleco, Perlmutter would purchase unsold inventory in exchange for 50% cash and 50% in "barter advertising credits" (basically a promise to pay for the future advertising expenses of Coleco). Over a four-year period, Perlmutter had received $144 million in goods and paid $73 million in cash along with providing $71 million in barter advertising credits to be paid in the future.

In 1988, he saw an opportunity as Coleco struggled under its debt due to the advent of the personal computer which impacted the sale of video games. Perlmutter bought all of Coleco's senior debt (with $85 million in face value) for $50 million, a substantial discount, becoming senior to their bondholders in the event of a bankruptcy. Although Perlmutter believed that a Coleco bankruptcy was probable, he also believed that the value of the Coleco's assets should be sufficient to cover the full $85 million in value that he had purchased. In July 1988, Coleco filed for Chapter 11 bankruptcy. The bondholders, suspicious over Perlmutter's close relationship with Coleco's management, sued Perlmutter alleging fraudulent conveyance over the barter advertising credits (which made up a very significant item on Coleco's balance sheet). After extensive negotiation, a settlement was reached whereby Coleco would be sold to Hasbro Corporation for $85 million and Perlmutter would accept $64 million for his now $90 million claim (principal plus interest) in exchange for the withdrawal of the lawsuit.

In 1994, Victor Kiam sold controlling interest of Remington Products to Isaac Perlmutter. Perlmutter became Vice President of Remington. Kiam and Perlmutter sold Remington to Vestar Capital Partners in 1996.

Isaac Perlmutter was a member of the board of directors of Marvel Comics beginning in April 1993 and was chairman of the board until March 1995.