Israeli wine is produced by hundreds of wineries, ranging in size from small boutique enterprises to large companies producing over ten million bottles per year.

Wine has been produced in the Land of Israel since biblical times. Wine was exported to Rome during the Roman period, but under the Muslim rulers the production was virtually wiped out. Under the Crusaders, winemaking was temporarily revived.

The modern Israeli wine industry was founded by Baron Edmond James de Rothschild, owner of the Bordeaux estate Château Lafite-Rothschild. Today, Israeli winemaking takes place in five vine-growing regions: Galil (Galilee, including the Golan Heights), the region most suited for viticulture due to its high elevation, cool breezes, marked day and night temperature changes and rich, well-drained soils; the Judean Hills, surrounding the city of Jerusalem; Shimshon (Samson), located between the Judean Hills and the Coastal Plain; the Negev, a semi-arid desert region, where drip irrigation has made grape growing possible; and the Sharon plain near the Mediterranean coast and just south of Haifa, surrounding the towns of Zichron Ya'akov and Binyamina, which is the largest grape growing area in Israel.

In 2011, Israeli wine exports totaled over $26.7 million. As of 2012, Israel had 12,355 acres of vineyards.

Viticulture has existed in the land of Israel since biblical times. In the book of Deuteronomy, the fruit of the vine was listed as one of the seven blessed species of fruit found in the land of Israel(Deut. 8:8). The location of Israel along a historic wine trading route between Mesopotamia and Egypt brought winemaking knowledge and influence to the area. Wine played a significant role in the religion of the early Israelites with images of grape growing, harvesting and winemaking often being used to illustrate religious ideals. In Roman times, wine from Israel was exported to Rome with the most sought after wines being vintage, dated with the name of the winemaker inscribed on the amphora.

Winemaking, limited under Islamic rule, was temporarily revived in the Crusader states from around 1100 to 1300 but the return of Islamic rule and the subsequent Jewish Diaspora extinguished the industry once again.

In 1848, a rabbi in Jerusalem founded the first documented winery in modern times but this establishment was short lived. In 1870, the first Jewish agricultural college, Mikveh Israel, was founded and featured a course on viticulture. The root of the modern Israeli wine industry can be traced to the late 19th century when the French Baron Edmond de Rothschild, owner of the Bordeaux estate Château Lafite-Rothschild, began importing French grape varieties and technical know how to the region. In 1882, he helped establish Carmel Winery with vineyards and wine production facilities in Rishon LeZion and Zikhron Ya'akov near Haifa. Still in operation today, Carmel is the largest producer of Israeli wine and has been at the forefront of many technical and historical advances in both winemaking and Israeli history.

One of the first telephones in Israel was installed at Carmel and the country's first Prime Minister, David Ben-Gurion, worked in Carmel's cellars in his youth.