Issy-les-Moulineaux (French pronunciation: [isi le mulino]) is a commune in the southwestern suburban area of Paris, France, lying on the left bank of the river Seine. Its citizens are called Isséens in French. It is one of Paris's entrances and is located 6.6 km (4.1 mi) from Notre Dame Cathedral, which is considered Kilometre Zero in France. On 1 January 2010, Issy-les-Moulineaux became part of the Grand Paris Seine Ouest agglomeration community, which merged into the Métropole du Grand Paris in January 2016.

Issy-les-Moulineaux has successfully moved its economy from an old manufacturing base to high value-added service sectors and is at the heart of the Val de Seine business district, the largest cluster of telecommunication and media businesses in France, hosting the headquarters of most major French television networks.

Issy-les-Moulineaux is a municipality located on the edge of the 15th arrondissement of Paris, along the main axis between Paris and Versailles, and on the left bank of the Seine. The town is situated 7.5 kilometres (4.7 mi) southwest of the Notre-Dame Cathedral in Paris, the central point of France's road network, and 3 kilometres (1.9 mi) from the town hall of the 15th arrondissement.

It is positioned 4 kilometres (2.5 mi) east of the sub-prefecture Boulogne-Billancourt and 11 kilometres (6.8 mi) southeast of the prefecture of Nanterre. Within its territory, Issy-les-Moulineaux encompasses the Île Saint-Germain, an island in the Seine.

Originally, Issy-les-Moulineaux was simply called Issy. The name Issy comes from the Medieval Latin Issiacum or Isciacum, perhaps meaning "estate of Isicius (or Iccius)", a Gallo-Roman landowner, although some think the name comes from a Celtic radical meaning "under the wood". Local legend recounted on the city's official website mentions an alternative origin of the name arising from a temple of the Egyptian goddess Isis said to be under the site of the Church of Saint Stephen.

In 1893 Issy officially became Issy-les-Moulineaux. Les Moulineaux was the name of a hamlet on the territory of the commune, apparently named Les Moulineaux due to the water mill or mills (French: moulins à eau) that stood there.

In July 1815 the Battle of Issy was fought in and around the village between Prussian and French forces. It was one of the last actions of the 'Hundred Days' campaign and was the final attempt to defend Paris against the armies of the Seventh Coalition.

On 1 January 1860, the city of Paris was enlarged by annexing neighboring communes. On that occasion, about a third of the commune of Issy-les-Moulineaux was annexed to Paris, and forms now the neighborhood of Javel, in the 15th arrondissement.