KWQC-TV (channel 6) is a television station licensed to Davenport, Iowa, United States, serving the Quad Cities area as an affiliate of NBC. Owned by Gray Media, the station maintains studios on Brady Street in downtown Davenport, and its transmitter is located in Bettendorf, Iowa.

KWQC first signed on the air on October 31, 1949, as WOC-TV. The station was founded by B. J. Palmer, founder of the Palmer College of Chiropractic (located directly across the street from the station's studios) along with WOC radio (1420 AM and 103.7 FM, now WLLR-FM). The WOC stations were also sister stations to WHO-AM/FM/TV in Des Moines. According to local legend, the WOC calls stood for "Wonders of Chiropractic", though the Palmer family never acknowledged the phrase in print or otherwise. WOC-TV has the distinction of being considered both Iowa's and the Quad Cities' first television station, carrying programming from all four networks at the time: (NBC, CBS, ABC and DuMont). However, it has always been a primary NBC affiliate owing to WOC radio's long-standing affiliation with the NBC Radio Network. Originally on channel 5, WOC-TV moved to channel 6 in 1952 because of interference with both Iowa State University's WOI-TV in Ames, and WNBQ-TV (now WMAQ-TV) in Chicago. During its early years, original programming on WOC-TV included the daily Show Boat children's show hosted by Cap'n Ernie from 1964 to 1974.

WOC-TV lost CBS when Rock Island–based WHBF-TV (channel 4) was launched in 1950. The two stations shared ABC until WQAD-TV (channel 8) signed on from Moline in 1963, and has since served as an exclusive NBC station. The station was also affiliated with the short-lived Paramount Television Network; in fact, it was one of that network's strongest affiliates, carrying programs such as Dixie Showboat, Hollywood Reel, and Hollywood Wrestling.

Channel 6 remained with the Palmer family's broadcasting division after Dr. Palmer's death in 1961. In 1986, Palmer Communications sold its Quad Cities radio properties to Vickie Anne Palmer and her then-husband J. Douglas Miller. As Federal Communications Commission (FCC) rules at the time did not allow separately-owned stations to share the same base call sign, channel 6 changed its calls to the current KWQC-TV on December 8. KWQC was sold to Broad Street Television in 1989 and to Young Broadcasting in 1995.

On June 6, 2013, Media General announced they would acquire Young Broadcasting in an all-stock deal. The merger was completed on November 12. The addition of KWQC to Media General's portfolio marked a return to Iowa for Media General, who had owned KIMT in Mason City from 2000 to 2006, though they would regain ownership of that station upon acquiring LIN Media in 2014. In September 2015, Media General announced the acquisition of Meredith Corporation in a cash and stock deal valued at $2.4 billion. If the deal was completed, KWQC and KIMT would have become Meredith's first television stations in its home state of Iowa.

Media General announced on January 27, 2016, that it was terminating the Meredith deal, and also announced that it was being acquired by Nexstar Broadcasting Group with the new company named Nexstar Media Group. As Nexstar already owns WHBF-TV, and since both WHBF and KWQC rank among the top four stations by daily ratings in the market, in order to comply with FCC ownership rules as well as planned changes to rules regarding same-market television stations which would prohibit future joint sales agreements, the company was required to sell either KWQC or WHBF to another company. WHBF's sister station KGCW was not affected, and could have either remained in its duopoly with WHBF or created a new duopoly with KWQC, as its ratings are below the top-four threshold. On June 3, 2016, it was announced that Nexstar would keep its existing assets and sell KWQC to Gray Television for $270 million. It represents a reunion of sorts as Gray previously managed the station when Young was encountering financial difficulties, but this time Gray acquired the station outright. That makes KWQC a sister station to KCRG-TV in Cedar Rapids, WIFR in Rockford and fellow NBC affiliate WMTV in Madison. The sale was completed on January 17, 2017.

On February 1, 2021, Gray Television announced its intent to purchase Quincy, Illinois–based Quincy Media for $925 million. The deal was completed on August 2, 2021, placing KWQC under common ownership with fellow NBC affiliates in several Illinois and Iowa markets, including WEEK-TV in Peoria, KTIV in Sioux City, KTTC in Rochester, Minnesota–Mason City, and WGEM-TV in Quincy (the long-time flagship television station of Quincy Media). Only KWWL in Waterloo–Cedar Rapids needed to be divested to a third party, as Gray Television already owns that market's ABC affiliate KCRG-TV, and had elected to keep KCRG-TV and sell KWWL due to the ownership conflict in that market. On April 29, Gray announced that it would divest KWWL, along with fellow NBC affiliate and Quincy Media sister station WREX in Rockford, to Allen Media Broadcasting, a subsidiary of Los Angeles based Entertainment Studios, for $380 million. WREX's divestiture was optional as FCC regulations would permit common ownership of WREX and WIFR-LD as WIFR-LD is a low-power station but the sale of KWWL was required as KWWL and KCRG-TV are both full-power stations.

KWQC-DT2 is the Ion Television–affiliated second digital subchannel of KWQC-TV, broadcasting in standard definition on channel 6.2.