Spanish is the official language of Guatemala, and is spoken by 93% of the population. Guatemalan Spanish is the local variant of the Spanish language.

Twenty-two Mayan languages are spoken, especially in rural areas, as well as two non-Mayan Amerindian languages: Xinca, an indigenous language, and Garifuna, an Arawakan language spoken on the Caribbean coast. According to the Language Law of 2003, the languages of Mayas, Xincas, and Garifunas are recognized as national languages.

German is spoken by more than 5,000 Germans citizens living permanently in Guatemala, as well as several thousand Guatemalans of German descent.